Correlation between Helicobacter pylori infection and gastrointestinal tumor in the physical examination population in Xi'an City
10.3969/j.issn.1006-2483.2024.01.024
- VernacularTitle:西安市体检人群幽门螺杆菌感染与胃肠道肿瘤的相关研究
- Author:
Lin HE
1
,
2
;
Yudong MU
1
,
2
;
Ying SUN
1
,
2
;
Zhimin YUAN
1
,
2
;
Jun YUAN
3
,
4
,
5
Author Information
1. Department of Clinical Laboratory , Shaanxi Cancer Hospital , Xi'
2. an , Shaanxi 710061 , China
3. Department of Clinical Laboratory , Shaanxi People'
4. s Hospital , Xi'
5. an , Shaanxi 710068 , China
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori（Hp）;
Gastrointestinal tumor;
Spatial distribution
- From:
Journal of Public Health and Preventive Medicine
2024;35(1):104-108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the spatial distribution of Helicobacter Pylori (Hp) infection and its correlation with gastrointestinal tumors in the physical examination population of Xi'an city, and to provide reference for the prevention of gastrointestinal tumors in this area. Methods A total of 23 200 subjects who underwent physical examination in 25 public hospitals in Xi'an from January 2019 to January 2023 were selected as the research objects. The basic Information of the patients was derived through the Hospital Information System (HIS), and all subjects underwent 13C-breath test and gastroenterological endoscope. ArcGIS 10.6 software was used to draw a statistical map of Hp infection in Xi 'an for spatial autocorrelation analysis. Hp infection in patients with different gastrointestinal tumors was analyzed. Results In this study population, there were 10 858 cases of Hp infection , with an infection rate of 46.80% ; among them , 5 491 cases were male, with an infection rate of 46.60% , and 5,367 cases were female, with an infection rate of 47.01% , and there was no significant difference in the infection rate between genders (P>0.05). The prevalence of HP infection was higher in the 30-year-old and 20-year-old groups, 55.62% and 42.71%, respectively, and the infection rate showed a first increase and then a decreasing trend with age (χ2trend = 6201.21, 6945.22 , P<0.001 ). The spatial distribution of Hp infection rate in the physical examination population of each administrative region county in Xi'an was globally spatially positively correlated, with spatial clustering (Moran's I=0.14, P=0.02). Local spatial autocorrelation showed that the five districts and counties presented high-high clustering. A total of 418 cases of gastrointestinal tumors were detected, with a detection rate of 1.80% , including 156 cases of gastric cancer , 85.90% of Hp infection rate, 106 cases of gastric mucosa-associated lymphoid tissue lymphoma, 83.02% of Hp infection rate, 98 cases of colon cancer, 80.61% of Hp infection rate, 58 cases of rectal cancer, 84.48% of Hp infection rate, and the differences were statistically significant (χ2=13.49, 16.16, 17.27, 24.66, P<0.05 for all). Conclusion The distribution of Hp infection in the physical examination population of Xi'an city has the characteristics of spatial aggregation and is related to gastrointestinal tumor diseases. It is suggested to carry out Hp infection education for the population in key areas to prevent the occurrence of gastrointestinal tumor diseases.
