Role of early dynamic PET/CT scan imaging with 18F-PSMA-1007 in staging and restaging prostate cancer in a tertiary private hospital
- Author:
Arrene Joy B. Baldonado
1
Author Information
1. Department of Radiological Sciences, Section of Nuclear Medicine and PET-CT center, Cardinal Santos Medical Center
- Publication Type:Journal Article
- Keywords:
18F-PSMA-1007 PET/CT scan;
Dynamic imaging;
Static imaging
- MeSH:
Prostatic Neoplasms
- From:
The Philippine Journal of Nuclear Medicine
2022;17(2):44-53
- CountryPhilippines
- Language:English
-
Abstract:
Introduction:18F-PSMA-1007 is a novel prostate-specific membrane antigen (PSMA)-based radiopharmaceutical for imaging
prostate cancer. The recommended imaging time is 60 minutes post-injection of the radiotracer. However,
during this time there is a physiologic accumulation of the radiotracer in the urinary bladder which sometimes
may obscure lesions adjacent to it.
Objective:This study aims to determine if early dynamic imaging in addition to the recommended 60-minute postinjection static imaging can improve the detection of PSMA-avid lesions in the staging and restaging of prostate
cancer.
Methods:This is a retrospective cross-sectional study of the detection rate of early dynamic and static imaging using
18F-PSMA-1007 PET/CT scan in patients with prostate cancer (PCa) who were referred for initial staging or
restaging. The McNemar test was used to compare the detection rate between the two imaging. Spearman
correlation was used to determine the correlation of Gleason score (GS), PSA, and SUVmax values.
Results:18F-PSMA-1007 PET/CT scans of 53 patients with prostate cancer, were referred for either staging (22/53) or
restaging (31/53), all of whom had undergone both early dynamic and static imaging. Among the 53 patients,
5 had 2 lesions each, for a total of 58 lesions were included in the analysis. There were 48/58 lesions detected
on both early dynamic and static imaging, 2/58 lesions were only detected in the early imaging, 1/58 lesions
was only detected in the static imaging, and 7/58 were not detected on both imaging. McNemar the test was
not statistically significant (p = 1.000) in the detection rate of the two methods. There is a positive correlation
between serum PSA levels and SUVmax measurements for all the patients. Only the correlation between the GS
and SUVmax in the static imaging of the staging group was statistically significant.
Conclusion:Early dynamic imaging may be an adjunctive procedure in detecting PSMA-avid lesions, particularly in the basal
segment of the prostate gland near the urinary bladder. However, it is not recommended as a standard
component of the comprehensive protocol for imaging using 18F-PSMA-1007 PET/CT in patients with PCa.
- Full text:17 (2) article 4.pdf
