Application of different microcarrier cell culture technologies in biological product field
10.13200/j.cnki.cjb.000080
- VernacularTitle:不同微载体细胞培养技术在生物制品领域的应用
- Author:
WANG Xiaoxun
- Publication Type:Journal Article
- Keywords:
Microcarrier;
Cell culture;
Biological product
- From:
Chinese Journal of Biologicals
2023;36(12):1515-1521+1529
- CountryChina
- Language:Chinese
-
Abstract:
The productivity of cells per unit area determines the scale-up potential of the cell culture process,and the largescale application of the microcarrier system provides space for the high-yield culture of anchorage-dependent animal cells. The microcarrier animal cell culture technology is suitable for efficient production process development and optimized amplification. In recent years,microcarrier-based culture technology has been widely used in various types of animal cell culture to produce many important biological products such as vaccines,enzymes,hormones,antibodies,interferons and other probiotics. In this paper,the research progress of domestic and foreign microcarrier cell culture technology,the comparison of new microcarriers and traditional microcarriers and their applications were reviewed,so as to provide reference for the in-depth research and application of large-scale cell culture technology based on new microcarriers.
