Advances in application of induced pluripotent stem cells in childhood genetic diseases
10.13200/j.cnki.cjb.000078
- VernacularTitle:诱导多能干细胞在儿童遗传性疾病治疗中的应用进展
- Author:
XIE Xin
- Publication Type:Journal Article
- Keywords:
Induced pluripotent stem cells(iPSCs);
Disease modeling;
Gene reprogramming;
Genetic disease
- From:
Chinese Journal of Biologicals
2023;36(12):1508-1514
- CountryChina
- Language:Chinese
-
Abstract:
Somatic cell reprogramming has developed rapidly in the field of modern biology. Induced pluripotent stem cells(iPSCs)obtained through somatic cell reprogramming are not only capable of self-renewal,but also have multidirectional differentiation potential,which plays an important role in disease modeling and regenerative medicine. This paper reviewed the gene reprogramming technology,the disease models of iPSCs and the application prospects of iPSCs in childhood genetic diseases,so as to provide a reference for the application of iPSCs in the research of mechanism and treatment of various genetic diseases.
