Association between platelet distribution width and hyperuricemia in healthy population
- VernacularTitle:健康体检人群血小板分布宽度与高尿酸血症的相关性分析
- Author:
Yan LIN
1
;
Junmei LU
1
;
Pengxiang QU
2
;
Gaizhi WENG
1
Author Information
- Publication Type:Journal Article
- Keywords: platelet distribution width; hyperuricemia; uric acid; physical examination
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(3):442-447
- CountryChina
- Language:Chinese
- Abstract: 【Objective】 To analyze the correlation between platelet distribution width (PDW) and hyperuricemia (HUA). 【Methods】 For this study we recruited 4 885 teaching and administrative staff of Xi’an Jiaotong University who took the physical examination in 2020 and met the requirements. The basic information, blood routine and serum biochemical index results were collected and analyzed retrospectively. Data were sorted by gender, and the serum UA level and the prevalence of HUA in different PDW quartiles were compared after dividing PDW into quartiles. The association of PDW with other indexes including age, serum biochemical indexes and blood routine indexes was analyzed. Then, the factors related to HUA in different genders were analyzed, and the independent influence of PDW on HUA was further analyzed. 【Results】 The serum UA level and prevalence of HUA were on the increase among different PDW quartiles both in two genders, and PDW level was positively correlated with serum UA level (P<0.05). In addition, PDW was correlated with age, fasting blood glucose, indicators related to liver and kidney function, and certain indexes of blood lipid and blood routine tests. Among the above indicators, glutamic-pyruvic transaminase, glutamic oxalacetic transaminase, creatinine, urea, white blood cell count, hematocrit, and blood lipid were all significantly associated with HUA in both genders (P<0.05). In addition, HUA significantly associated with platelet count in males (P<0.05), but with age, fasting blood glucose, hemoglobin, red blood cell distribution width, and PDW in females (P<0.05). After excluding the above confounding factors, the risk of HUA in males with high levels of PDW was still significantly increased (P<0.05), but there was no significant difference in females (P>0.05). 【Conclusion】 PDW is correlated with HUA, and PDW may be an independent risk factor for HUA in males. However, further study is needed.
