Changes of spontaneous brain activity in end-stage renal disease patients: A study based on dynamic regional homogeneity

Hang SU; Zhaoyao Luo; Hui Wang; Ronghua HE; Zhuanqin Ren; Kun Zhang; Hongzhe Tian; Yuanshuo Ouyang; Haining LI; Yuchen Zhang

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Changes of spontaneous brain activity in end-stage renal disease patients: A study based on dynamic regional homogeneity

VernacularTitle:基于动态局部一致性研究终末期肾病患者自发脑活动的变化
Author: Hang SU ^{1
,

2} ; Zhaoyao LUO ¹ ; Hui WANG ¹ ; Ronghua HE ³ ; Zhuanqin REN ³ ; Kun ZHANG ³ ; Hongzhe TIAN ³ ; Yuanshuo OUYANG ⁴ ; Haining LI ¹ ; Yuchen ZHANG ¹
Author Information

1. Department of Nuclear Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061
2. Department of Diagnostic Radiology, Baoji Central Hospital, Baoji 721008
3. Department of Diagnostic Radiology, Baoji Central Hospital, Baoji 721008
4. Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences of Xi’an Jiaotong University Health Science Center, Xi’an 710061, China
Publication Type:Journal Article
Keywords: end-stage renal disease; hemodialysis; dynamic regional homogeneity; resting-state functional magnetic resonance imaging; cognitive impairment
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(3):432-436
CountryChina
Language:Chinese
Abstract: 【Objective】 To investigate dynamic regional homogeneity (dReHo) abnormality in end-stage renal disease (ESRD) patients by using resting-state functional magnetic resonance imaging (rs-fMRI). 【Methods】 A total of 26 ESRD patients and 26 healthy controls (HC) matched in gender, education level and age were included. Rs-fMRI scanning was performed in all subjects. All the subjects were tested by using auditory verbal learning test Huashan version (AVLT-H) and Montreal Cognitive Assessment (MoCA) to assess cognitive function before collection of MRI data. T-test was used to observe the difference in dReHo at global level between the two groups. Pearson and Spearman correlation analyses were made to estimate the correlation between abnormal brain regions and clinical scales. 【Results】 Compared with HC group, the dReHo value in ESRD patients reduced on the bilateral superior margin gyrus, left insula, left posterior central gyrus, and left putamen (P<0.05, replacement test correction). The dReHo values of left superior margin gyrus (r=-0.534, P=0.005) and left insula in ESRD patients (r=-0.422, P=0.032) were negatively correlated with the LR-S score, and the dReHo value of the left margin was negatively correlated with the SR-S score (r=-0.468, P=0.016). 【Conclusion】 There are abnormal dReHo values in several brain regions in ESRD patients during resting state, which is related to the patients’ cognitive function. The variation of dReHo value provides a new objective imaging basis for evaluating the cognitive function of ESRD patients.