Correlation between biomarker EHD3 and immune cell infiltration in gastric cancer
- VernacularTitle:生物标志物EHD3与胃癌中免疫细胞浸润的相关性研究
- Author:
Yuanyuan WANG
1
,
2
;
Ni ZHOU
1
,
2
;
Da WANG
1
;
Ping MAI
3
Author Information
- Publication Type:Journal Article
- Keywords: EHD3; gastric cancer; prognosis; biomarker; immune infiltration
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(3):374-382
- CountryChina
- Language:Chinese
- Abstract: 【Objective】 To investigate the prognostic role of EHD3 and its association with immune cell infiltration in gastric cancer. 【Methods】 In this study, EHD3 expression was analyzed using RNA sequencing data from Cancer Genome Atlas (TCGA). Differential analysis, functional enrichment, immune infiltration, immune checkpoint exploration, and clinical baseline data analysis were performed. Independent prognostic factors were identified using univariate and multivariate Cox regression analysis; a column diagram model was developed and evaluated using C-index and calibration diagrams. 【Results】 EHD3 was significantly upregulated in STAD and functional enrichment analysis showed that EHD3 expression was associated with immune response, with most immune cells and immune checkpoints positively correlated with their expression. Cox regression showed that EHD3 was an independent prognostic factor in STAD patients (HR=2.112, 95% CI: 1.340-3.327, P=0.001). 【Conclusion】 EHD3 is considered to be a novel prognostic biomarker for STAD patients, and this study provides a potential therapeutic target for STAD treatment.
