Advances in research on IL-18 in the pathogenesis of allergic airway diseases

VernacularTitle:IL-18在过敏性气道疾病中的作用研究进展
Author: Junling WANG ^{1
,

2
,

3} ; Shaoheng HE ⁴
Author Information

1. Department of Critical Care Medicine, Henan Provincial People’s Hospital
2. Zhengzhou University People’s Hospital, Zhengzhou 450003
3. Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China
4. Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China
Publication Type:Journal Article
Keywords: interleukin-18 (IL-18); allergic rhinitis; allergic asthma
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(4):654-658
CountryChina
Language:Chinese
Abstract: The prevalence of allergic airway diseases has been increasing in recent years. Interleukin-18 (IL-18) plays an imperative role in allergic airway diseases by binding to IL-18Rα, thereby initiating the downstream proinflammatory pathway. IL-18 also binds to IL-18BP, thus inhibiting its binding to IL-18Rα. Therefore, further understanding of the role of IL-18 and its action mechanisms in allergic airway diseases is important for the treatment of allergic airway diseases, and for the development of IL-18-related biological agents.