The curative effect and mechanism of magnetic hyperthermia in the treatment of knee osteoarthritis

Fei Gao; Longlong DU; Tong Wang; Xuefeng LI; Yuke Zhong; Qimeng Gao; Rui Chen; Puwei Yuan; Lingyun Zhao

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The curative effect and mechanism of magnetic hyperthermia in the treatment of knee osteoarthritis

VernacularTitle:应用磁热疗法治疗膝骨关节炎的疗效观察及机制
Author: Fei GAO ¹ ; Longlong DU ² ; Tong WANG ² ; Xuefeng LI ² ; Yuke ZHONG ² ; Qimeng GAO ² ; Rui CHEN ² ; Puwei YUAN ² ; Lingyun ZHAO ³
Author Information

1. Institute of Integrated Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046
2. The Affiliated Hospital, Shaanxi University of Chinese Medicine, Xianyang 712000
3. School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China
Publication Type:Journal Article
Keywords: knee osteoarthritis; magnetic hyperthermia; ferrimagnetic vortex domain iron oxide nanoring; MicroCT
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(5):784-793
CountryChina
Language:Chinese
Abstract: 【Objective】 We combined the concept of traditional medicine with magnetic induction technology, originally brought up the research concept of magnetic hyperthermia to cure KOA, explored the mechanism and constructed a new treatment of KOA with modern medical features. 【Methods】 Through establishing a primary KOA model in rats and constructing ferrimagnetic vortex domain iron oxide nanorings (FVIOs) as a platform for highly efficient magnetic hyperthermia agent, the lesions of KOA were heated accurately under the low-intensity magnetic field. We confirmed the curative effect through the results of pain perception, histopathology, knee joint morphology and microscopic bone structure and the content of serum inflammatory factor, to study the therapeutic mechanism of magnetic hyperthermia for KOA. 【Results】 Compared with the model group, the recovery of mechanical pain threshold after magnetic hyperthermia improved by approximately 48.9%; the degree of hyperemia and edema of joint capsule and synovial tissue and the wear degree of joint cartilage surface, were significantly reduced; the Mankin and OARSI scores decreased by about 33% and 20%, respectively; the MicroCT results indicated that the degree of hardening of the subchondral bone also improved; the expression of inflammatory factors in the serum was reduced. 【Conclusion】 In this study, we utilized the FVIOs as a high-efficiency magnetic hyperthermia platform for the treatment of KOA. The efficacy of magnetic hyperthermia on KOA is clarified, and the mechanism is related to the inhibition of inflammatory factors.