Efficacy of local injection of triamcinolone acetonide combined with surgery in the treatment of mass-type granulomatous mastitis

Yanjie LI; Yonggang LÜ; Fuqing JI; Xin XU; Jun Yun; Jun YI

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Efficacy of local injection of triamcinolone acetonide combined with surgery in the treatment of mass-type granulomatous mastitis

VernacularTitle:局部注射曲安奈德联合手术治疗肿块型肉芽肿性乳腺炎的疗效分析
Author: Yanjie LI ¹ ; Yonggang LÜ ² ; Fuqing JI ² ; Xin XU ¹ ; Jun YUN ¹ ; Jun YI ¹
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1. Department of Thyroid, Breast & Vascular Surgery, The First Affiliated Hospital of Air Force Medical University, Xi’an 710032
2. Department of Thyroid & Breast Surgery, Xi’an No.3 Hospital, The Affiliated Hospital of Northwest University of Xi’an, Xi’an 710018, China
Publication Type:Journal Article
Keywords: triamcinolone acetonide; granulomatous mastitis; local injection; curative effect
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(5):773-778
CountryChina
Language:Chinese
Abstract: 【Objective】 To analyze the efficacy and safety of intralesional triamcinolone acetonide in the treatment of mass granulomatous mastitis (GLM). 【Methods】 Retrospective analysis was made on 67 patients with GLM who were treated in Xijing Hospital from July 2021 to May 2022 and met the inclusion criteria. Among them, 31 patients were treated with local injection of triamcinolone acetonide, while 36 ones were treated with oral methylprednisolone. All the included patients underwent surgical treatment after their condition met the surgical criteria, and the follow-up period lasted for up to six months after surgery. The two groups were compared in improvement of symptoms and signs, treatment time, clinical effectiveness and safety, and recurrence rate. 【Results】 The effective rate of triamcinolone acetonide group and methylprednisolone group was 100%, but the clinical cure rate was significantly higher in triamcinolone acetonide group than in methylprednisolone group in stratified analysis (P<0.05). The improvement time of symptoms and signs in triamcinolone acetonide group was significantly shorter than that in methylprednisolone group (P<0.05). The incidence of side effects in triamcinolone acetonide group was also significantly reduced compared to methylprednisolone group (P<0.05). Follow-up for half a year showed no recurrence in both groups. 【Conclusion】 Compared with the traditional oral methylprednisolone group, local injection of triamcinolone acetonide in the treatment of mass granulomatous mastitis can rapidly relieve clinical symptoms and signs, shorten treatment time, and has higher efficiency and fewer side effects. Local injection of hormone combined with surgery is effective in treating mass granulomatous mastitis with low recurrence rate.