Expression level and clinical significance of SOCS1 in the serum of patients with chronic HBV-related liver disease

Chenrui Liu; Dandan Cui; Jing LI; Miaomiao Zhang; Fenxiang LI; Lihong XU; Shuangsuo Dang; Yaping LI

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Expression level and clinical significance of SOCS1 in the serum of patients with chronic HBV-related liver disease

VernacularTitle:SOCS1在慢性HBV相关性肝病患者血清中的表达水平及临床意义
Author: Chenrui LIU ¹ ; Dandan CUI ¹ ; Jing LI ¹ ; Miaomiao ZHANG ¹ ; Fenxiang LI ¹ ; Lihong XU ¹ ; Shuangsuo DANG ¹ ; Yaping LI ¹
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1. Department of Infection, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
Publication Type:Journal Article
Keywords: suppressor of cytokine signaling 1 (SOCS1); chronic hepatitis B; HBV-associated chronic acute liver failure (HBV-ACLF); interleukin-6
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(6):924-929
CountryChina
Language:Chinese
Abstract: 【Objective】 To study the expression levels of suppressor of cytokine signaling 1 (SOCS1) and its clinical significance in hepatitis B virus (HBV)-related liver diseases. 【Methods】 For this study we enrolled 25 patients with chronic hepatitis B (CHB), hepatitis B cirrhosis, or HBV-associated chronic acute liver failure (HBV-ACLF), and 25 healthy controls. The expression levels of SOCS1 mRNA in peripheral blood mononuclear cells (PBMCs) were determined using the RT-PCR method. The levels of SOCS1 and interleukin-6 (IL-6) in the plasma of patients with chronic liver diseases and healthy controls were measured using the ELISA method. The relative expression levels of SOCS1, SOCS1 mRNA, and other laboratory test indicators such as HBV-DNA, alanine aminotransferase (ALT), aspartate aminotransferase (AST), prothrombin activity (PTA) and total bilirubin (TBil) were compared among the groups. Additionally, the correlation between the expression levels of SOCS1 mRNA and the aforementioned laboratory indicators was assessed. 【Results】 The expression levels of SOCS1 mRNA and serum SOCS1 were highest in the HBV-ACLF group, followed by the cirrhosis group, and lowest in the healthy control group, with statistically significant differences (F=109.65, P<0.001). The relative expression of SOCS1 mRNA was positively correlated with TBil (r=0.89, P<0.001), ALT (r=0.89, P<0.001), AST (r=0.84, P<0.001) and IL-6 (r=0.93, P<0.001), but negatively correlated with PTA (r=-0.89, P<0.001) and was not significantly correlated with HBV-DNA (P=0.28). 【Conclusion】 The expression levels of SOCS1 in patients with HBV-related chronic liver diseases can reflect the severity of the disease and show a significant correlation with indicators used to assess the severity of liver diseases.