Remnant cholesterol is associated with triglyceride and glucose index in young and middle-aged patients with ischemic stroke

Youyou Zhang; Ruirui Jia; Long Wang; Dong Chen; Hui Wang; Zhaoyang LI

Return

Remnant cholesterol is associated with triglyceride and glucose index in young and middle-aged patients with ischemic stroke

VernacularTitle:中青年缺血性脑卒中患者TyG指数与残余胆固醇的关联研究
Author: Youyou ZHANG ¹ ; Ruirui JIA ¹ ; Long WANG ¹ ; Dong CHEN ² ; Hui WANG ¹ ; Zhaoyang LI ³
Author Information

1. Department of Geriatric Neurology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004
2. Department of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004
3. School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, China
Publication Type:Journal Article
Keywords: ischemic stroke; triglyceride and glucose index; remnant cholesterol; young and middle-aged patients
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(6):910-914
CountryChina
Language:Chinese
Abstract: 【Objective】 To investigate the association between remnant cholesterol (RC) and triglyceride and glucose (TyG) index in young and middle-aged patients with ischemic stroke. 【Methods】 A total of 268 patients were divided into two groups, namely low TyG index group (n=134) and high TyG index group (n=134). Characteristics of the study population and metabolism risk factors (TC, TG, HDL-C, LDL-C, UA) were collected from biochemical test results. Spearman correlation analysis was used to analyze the correlation between metabolism risk factors and TyG index. Multivariate conditional logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for RC and TyG index. 【Results】 Compared with the low TyG index group, significant differences were observed for BMI, history of diabetes, history of hypertension, SBP, DBP, FBG, TC, TG, LDL-C, RC, UA, and TyG index in high TyG index group. No significant differences were observed in age, gender, smoking status, or drinking status, HDL-C between the two groups. Spearman correlation analysis indicated that significant linear associations were observed between BMI, SBP, DBP, FBG, TC, TG, HDL-C, LDL-C, RC, UA and TyG index. Logistic regression analysis revealed that the RC, BMI, hypertension, diabetes, TC, LDL-C, and UA were significantly associated with the risk of increased level of TyG index. After adjusted analysis by RC, BMI, hypertension, diabetes, TC, LDL-C, and UA, only RC was significantly associated with an increased risk of increased level of TyG index. 【Conclusion】 Remnant cholesterol was associated with an increased risk of elevated TyG index level in young and middle-aged patients with ischemic stroke.