Relationship between Coronary Artery Calcium Score by Multidetector Computed Tomography and Plaque Components by Virtual Histology Intravascular Ultrasound.
10.3346/jkms.2011.26.8.1052
- Author:
Yun Ha CHOI
1
;
Young Joon HONG
;
In Hyae PARK
;
Myung Ho JEONG
;
Khurshid AHMED
;
Seung Hwan HWANG
;
Min Goo LEE
;
Keun Ho PARK
;
Doo Sun SIM
;
Ju Han KIM
;
Youngkeun AHN
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Jung Chaee KANG
Author Information
1. The Heart Center, Chonnam National University Hospital, Gwangju, Korea. hyj200@hanmail.net
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Coronary Disease;
Multidetector Computed Tomography;
Coronary Artery Calcium Score;
Plaque;
Intravascular Ultrasound
- MeSH:
Adult;
Aged;
Calcinosis/*diagnosis/radiography/ultrasonography;
Calcium/*analysis;
Coronary Angiography;
Coronary Artery Disease/*diagnosis/radiography/ultrasonography;
Coronary Vessels/pathology;
Female;
Humans;
Male;
Middle Aged;
*Multidetector Computed Tomography;
Necrosis;
Plaque, Atherosclerotic/*pathology;
*Ultrasonography, Interventional
- From:Journal of Korean Medical Science
2011;26(8):1052-1060
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to evaluate the relationship between coronary artery calcium score (CACS) assessed by multidetector computed tomography (MDCT) and plaque components assessed by virtual histology-intravascular ultrasound (VH-IVUS) in 172 coronary artery disease (CAD) patients with 250 coronary lesions. CACS was assessed according to Agatston scoring method by MDCT and patients were divided into four groups: Group I (CACS = 0 [n = 52]); Group II (CACS = 1-100 [n = 99]); Group III (CACS = 101-400 [n = 84]); and Group IV (CACS > 400 [n = 15]). Total atheroma volume was greatest in Group IV (152 +/- 132 microL vs 171 +/- 114 microL vs 195 +/- 149 microL vs 321+/-182 microL, P < 0.001). The absolute dense calcium (DC) and necrotic core (NC) volumes were greatest, and relative DC volume was greatest in Group IV (5.5 +/- 6.6 microL vs 11.0 +/- 10.3 microL vs 15.6 +/- 13.6 microL vs 36.6 +/- 18.2 microL, P < 0.001, and 14.8 +/- 18.2 microL vs 19.5 +/- 18.9 microL vs 22.5 +/- 19.1 microL vs 41.7 +/- 27.9 microL, P < 0.001, and 6.4 +/- 5.3% vs 11.0 +/- 6.2% vs 14.0 +/- 6.5% vs 20.0 +/- 7.8%, P < 0.001, respectively). The absolute plaque and DC and NC volumes and the relative DC volume correlated positively with calcium score. CAD patients with high calcium score have more vulnerable plaque components (greater DC and NC-containing plaques) than those with low calcium score.
