Vitamin K Supplement Along with Vitamin D and Calcium Reduced Serum Concentration of Undercarboxylated Osteocalcin While Increasing Bone Mineral Density in Korean Postmenopausal Women over Sixty-Years-Old.
10.3346/jkms.2011.26.8.1093
- Author:
Sang Hyeon JE
1
;
Nam Seok JOO
;
Beom hee CHOI
;
Kwang Min KIM
;
Bom Taeck KIM
;
Sat Byul PARK
;
Doo Yeoun CHO
;
Kyu Nam KIM
;
Duck Joo LEE
Author Information
1. Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea. djleemd@msn.com
- Publication Type:Controlled Clinical Trial ; Original Article ; Randomized Controlled Trial
- Keywords:
Vitamin K;
Undercarboxylated osteocalcin;
Bone Mineral Density;
Korean Women
- MeSH:
Aged;
Bone Density/*drug effects;
Calcium/*administration & dosage;
Dietary Supplements;
Female;
Humans;
Middle Aged;
Osteocalcin/*blood;
Postmenopause;
Republic of Korea;
Vitamin D/*administration & dosage;
Vitamin K/*administration & dosage
- From:Journal of Korean Medical Science
2011;26(8):1093-1098
- CountryRepublic of Korea
- Language:English
-
Abstract:
There are inconsistent findings on the effects of vitamin K on bone mineral density (BMD) and undercarboxylated osteocalcin (UcOC). The present intervention study evaluated the effect in subjects over 60-yr-old. The vitamin K group (vitamin K + vitamin D + calcium supplement; 15 mg of vitamin K2 [menatetrenone] three times daily, 400 IU of vitamin D once a day, and 315 mg of calcium twice daily) and the control group (vitamin D + calcium supplement) were randomly assigned. During the six months of treatment, seventy eight women participated (38 in the vitamin K group and 40 in the control group) and 45 women completed the study. The baseline characteristics of study participants did not differ between the vitamin K and the control groups. In a per protocol analysis after 6 months, L3 bone mineral density has increased statistically significantly in the vitamin K group compared to the control group (0.01 +/- 0.03 g/cm2 vs -0.008 +/- 0.04 g/cm2, P = 0.049). UcOC concentration was also significantly decreased in the vitamin K group (-1.6 +/- 1.6 ng/dL vs -0.4 +/- 1.1 ng/dL, P = 0.008). In conclusion, addition of vitamin K to vitamin D and calcium supplements in the postmenopausal Korean women increase the L3 BMD and reduce the UcOC concentration.
