Distribution of rs8022522 and rs12894524 polymorphisms of miR-208 gene in Guangxi population
- VernacularTitle:miR-208基因rs8022522和rs12894524位点多态性在广西人群的分布
- Author:
Chao LIU
1
;
Yanping LUO
1
;
Xixi GU
1
;
Jianming CHEN
1
;
Yan LAN
2
;
Yesheng WEI
1
Author Information
- Publication Type:Journal Article
- Keywords: miR-208; genetic polymorphism; Guangxi population; lipoprotein
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(1):76-81
- CountryChina
- Language:Chinese
- Abstract: 【Objective】 To explore the distribution of polymorphisms of miR-208 genes rs8022522 and rs12894524 locus in Guangxi healthy population and compare the differences in the polymorphism distribution in different population. 【Methods】 SNPscan technology was used to detect genotypes of rs8022522 and rs12894524 from 297 healthy people in Guangxi, and the results were compared with other populations from Human genome Haplotype Map(HapMap) data. 【Results】 Three genotypes, namely, AA (2.7%), AG (24.2%) and GG (73.1%), in rs8022522 were found, with the allele frequencies of A and G being 14.8% and 85.2%. The genotypes of rs12894524 locus were TT (1.3%), TG (13.5%) and GG (85.2%), and the frequency of T and G allele was 8.1% and 91.9%, respectively. rs8022522 and rs12894524 locus genotypes and allele frequencies were significantly different from HapMap-CEU, HapMap- YRI and HapMap-TSI (P<0.05). Compared with HapMap-JPT and HapMap-CHB, there was no significant difference in genotype or allele frequency between the two sites (P>0.05). As for the blood lipid level among the three genotypes in rs8022522, the level of high density lipoprotein cholesterol (HDL-C) with GG genotype was significantly different from that in AG group (P<0.05). 【Conclusion】 The polymorphisms of rs8022522 and rs12894524 of miR-208 gene in Guangxi population are different from those in other regions to varying degrees. The polymorphism of rs8022522 locus is related to the level of HDL-C.
