Associations of genetic variants in M3 receptor with blood pressure responses to salt and potassium intake

Xi Zhang; Guilin HU; Zejiaxin Niu; Mingfei DU; Ting Zou; Xiaoyu Zhang; Lan Wang; Chao Chu; Yueyuan Liao; Qiong MA; Dan Wang; Keke Wang; Hao Jia; Chen Chen; Yu Yan; Yue Sun; Tongshuai Guo; Jie Zhang; Weihua Gao; Ruichen Yan; Ke Gao; Wenjing Luo; Jianjun MU; Yang Wang

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Associations of genetic variants in M3 receptor with blood pressure responses to salt and potassium intake

VernacularTitle:M3受体遗传变异与血压钠钾反应性的关联研究
Author: Xi ZHANG ¹ ; Guilin HU ¹ ; Zejiaxin NIU ¹ ; Mingfei DU ¹ ; Ting ZOU ¹ ; Xiaoyu ZHANG ² ; Lan WANG ³ ; Chao CHU ¹ ; Yueyuan LIAO ¹ ; Qiong MA ¹ ; Dan WANG ¹ ; Keke WANG ¹ ; Hao JIA ¹ ; Chen CHEN ¹ ; Yu YAN ¹ ; Yue SUN ¹ ; Tongshuai GUO ¹ ; Jie ZHANG ⁴ ; Weihua GAO ⁵ ; Ruichen YAN ¹ ; Ke GAO ¹ ; Wenjing LUO ¹ ; Jianjun MU ¹ ; Yang WANG ^{1
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Author Information

1. Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061
2. Department of Cardiology, Northwest Women’s and Children’s Hospital, Xi’an 710003
3. Department of Cardiology, Xi’an International Medical Center Hospital, Xi’an 710100
4. Department of Cardiology, Xi’an People’s Hospital, Xi’an 710004
5. Department of Cardiology, Xi’an No.1 Hospital, Xi’an 710002
6. Global Health Institute, Xi’an Jiaotong University, Xi’an 710061, China
Publication Type:Journal Article
Keywords: M3 muscarinic acetylcholine receptor; genetic polymorphism; blood pressure; salt; potassium
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(1):46-54
CountryChina
Language:Chinese
Abstract: 【Objective】 M3 muscarinic acetylcholine receptor(M3 receptor), encoded by CHRM3 gene, is widely distributed in the cardiovascular system and plays an important role in cardiac regulation. The aim of this study was to assess the association of genetic variants in M3 receptor with blood pressure(BP) responses to controlled dietary sodium and potassium interventions. 【Methods】 A total of 333 subjects from 124 families were recruited from the rural areas of northern China. After a three-day baseline observation, they were sequentially on a seven-day low-salt diet, a seven-day high-salt diet, and a seven-day high-salt diet plus potassium supplementation. Thirteen CHRM3 single nucleotide polymorphisms(SNPs) were selected for analysis. 【Results】 SNP rs10802811 of the CHRM3 was significantly associated with diastolic BP(DBP) and mean arterial pressure(MAP) responses to both low-salt and high-salt diets while SNPs rs6429147, rs373288072, rs114677844 and rs663148 showed significant associations with systolic BP(SBP) and MAP responses to high-salt diet. In addition, SNP rs6692904 was significantly associated with SBP, DBP and MAP responses to high-salt diet with potassium supplementation. 【Conclusion】 Genetic variants in M3 receptor are significantly associated with BP responses to sodium and potassium intervention, suggesting that M3 receptor may be mechanistically involved in BP salt and potassium sensitivity.