Association of genetic variants in uromodulin with blood pressure responses to dietary salt and potassium intake

Yan WU; Mingfei DU; Xi Zhang; Lan Wang; Guilin HU; Zejiaxin Niu; Ting Zou; Xiaoyu Zhang; Chao Chu; Yueyuan Liao; Qiong MA; Dan Wang; Keke Wang; Hao Jia; Chen Chen; Yu Yan; Yue Sun; Tongshuai Guo; Jie Zhang; Weihua Gao; Ziyue Man; Ke Gao; Wenjing Luo; Jianjun MU; Yang Wang

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Association of genetic variants in uromodulin with blood pressure responses to dietary salt and potassium intake

VernacularTitle:尿调节素基因多态性与血压钠钾反应性的相关性分析
Author: Yan WU ¹ ; Mingfei DU ¹ ; Xi ZHANG ¹ ; Lan WANG ² ; Guilin HU ¹ ; Zejiaxin NIU ¹ ; Ting ZOU ¹ ; Xiaoyu ZHANG ³ ; Chao CHU ¹ ; Yueyuan LIAO ¹ ; Qiong MA ¹ ; Dan WANG ¹ ; Keke WANG ¹ ; Hao JIA ¹ ; Chen CHEN ¹ ; Yu YAN ¹ ; Yue SUN ¹ ; Tongshuai GUO ¹ ; Jie ZHANG ⁴ ; Weihua GAO ⁵ ; Ziyue MAN ¹ ; Ke GAO ¹ ; Wenjing LUO ¹ ; Jianjun MU ¹ ; Yang WANG ^{1
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Author Information

1. Department of Cardiovascular Medicine,The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061
2. Department of Cardiology, Xi’an International Medical Center Hospital, Xi’an 710100
3. Department of Cardiology, Northwest Women’s and Children’s Hospital, Xi’an 710003
4. Department of Cardiology, Xi’an People’s Hospital, Xi’an 710004
5. Department of Cardiology, Xi’an No. 1 Hospital, Xi’an 710002
6. Global Health Institute, Xi’an Jiaotong University, Xi’an 710061, China
Publication Type:Journal Article
Keywords: uromodulin; genetic polymorphism; blood pressure; salt; potassium
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(1):38-45
CountryChina
Language:Chinese
Abstract: 【Objective】 Based on our previously established salt-sensitive hypertension cohort, we aimed to examine the association of genetic variants in uromodulin with blood pressure(BP) responses to dietary interventions of sodium and potassium intake. 【Methods】 In 2004, 514 subjects from 124 families in Mei County, Shaanxi Province, were recruited to establish the salt-sensitive hypertension study cohort. Among them, 333 non-parent subjects were selected and sequentially maintained on a normal-diet for 3 days, low-salt diet for 7 days, then a high-salt diet for 7 days and a high-salt diet with potassium supplementation for another 7 days. Thirteen single nucleotide polymorphisms(SNPs) in the uromodulin gene were genotyped on the MassARRAY platform. 【Results】 BP levels decreased from the baseline to low-salt diet, increased from low-salt to high-salt diet, and decreased again from the high-salt diet to the high-salt plus potassium supplementation intervention. SNPs rs77875418 and rs4997081 of the uromodulin gene were significantly associated with diastolic BP(DBP) and mean arterial pressure(MAP) responses to high-salt diet. In addition, SNPs rs77875418, rs79245268, rs4293393, rs6497476, rs4997081, rs13333226, and rs12917707 were significantly associated with systolic BP(SBP), DBP, and MAP responses to high-salt diet with potassium supplementation. 【Conclusion】 Genetic variants in uromodulin gene are significantly associated with BP responses to sodium and potassium supplementation, suggesting that uromodulin may be mechanistically involved in BP sodium-sensitivity and potassium-sensitivity.