Association of genetic variants in NEDD4L with blood pressure responses to dietary salt and potassium intake

Zejiaxin Niu; Mingfei DU; Guilin HU; Xi Zhang; Dan Wang; Lan Wang; Wenjing Luo; Mingke Chang; Ting Zou; Xiaoyu Zhang; Yu Yan; Chao Chu; Yueyuan Liao; Qiong MA; Keke Wang; Hao Jia; Chen Chen; Yue Sun; Tongshuai Guo; Jie Zhang; Weihua Gao; Ziyue Man; Ke Gao; Jianjun MU; Yang Wang

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Association of genetic variants in NEDD4L with blood pressure responses to dietary salt and potassium intake

VernacularTitle:NEDD4L基因多态性与血压钠钾反应性的相关性分析
Author: Zejiaxin NIU ¹ ; Mingfei DU ¹ ; Guilin HU ¹ ; Xi ZHANG ¹ ; Dan WANG ¹ ; Lan WANG ² ; Wenjing LUO ¹ ; Mingke CHANG ¹ ; Ting ZOU ¹ ; Xiaoyu ZHANG ³ ; Yu YAN ¹ ; Chao CHU ¹ ; Yueyuan LIAO ¹ ; Qiong MA ¹ ; Keke WANG ¹ ; Hao JIA ¹ ; Chen CHEN ¹ ; Yue SUN ¹ ; Tongshuai GUO ¹ ; Jie ZHANG ⁴ ; Weihua GAO ⁵ ; Ziyue MAN ¹ ; Ke GAO ¹ ; Jianjun MU ¹ ; Yang WANG ^{1
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Author Information

1. Department of Cardiovascular Medicine,The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061
2. Department of Cardiology, Xi’an International Medical Center Hospital, Xi’an 710100
3. Department of Cardiology, Northwest Women’s and Children’s Hospital, Xi’an 710003
4. Department of Cardiology, Xi’an People’s Hospital, Xi’an 710004
5. Department of Cardiology, Xi’an No.1 Hospital, Xi’an 710002
6. Global Health Institute, Xi’an Jiaotong University, Xi’an 710061, China
Publication Type:Journal Article
Keywords: NEDD4L; genetic polymorphism; blood pressure; salt sensitivity; potassium
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(1):30-37
CountryChina
Language:Chinese
Abstract: 【Objective】 4-like protein with down-regulated expression and development in neural precursor cells (NEDD4L) plays an important role in blood pressure (BP) regulation and sodium homeostasis by regulating epithelial sodium channel protein. In this study, we aimed to explore the relationship of NEDD4L gene polymorphisms with BP responses to sodium and potassium intake. 【Methods】 In 2004, 514 subjects from 124 families in Meixian County, Shaanxi Province, were recruited to establish a salt-sensitive hypertension study cohort. All the subjects received a 3-day baseline survey, a 7-day low-salt diet, a 7-day high-salt diet, and finally a 7-day high-salt and potassium supplementation. Their BP was measured and peripheral blood samples were collected at different intervention periods. The 14 gene polymorphisms of NEDD4L gene were genotyped and analyzed by MassARRAY platform. 【Results】 BP decreased on a low-salt diet, and significantly increased on a high-salt diet, and decreased again after potassium supplementation. NEDD4L SNPs rs74408486 were significantly associated with systolic BP, diastolic BP and mean arterial pressure responses to the low-salt diet. SNPs rs292449 and rs2288775 were significantly associated with pulse pressure response to the high-salt diet. In addition, SNPs rs563283 and rs292449 were significantly associated with diastolic BP, mean arterial pressure, and pulse pressure responses to high-salt and potassium supplementation diet. 【Conclusion】 NEDD4L gene polymorphisms were significantly associated with BP responses to sodium and potassium intake, suggesting that NEDD4L gene may be involved in the development of salt sensitivity and potassium sensitivity.