Correlation between monocytes and high-density lipoprotein cholesterol ratio and coronary artery stenosis in patients with unstable angina pectoris
- VernacularTitle:单核细胞/高密度脂蛋白胆固醇比值与不稳定型心绞痛患者冠状动脉病变狭窄程度的相关性研究
- Author:
Zejiaxin NIU
1
;
Dan WANG
1
;
Guilin HU
1
;
Mingke CHANG
1
;
Tongshuai GUO
1
;
Yu YAN
1
;
Baoyu GAN
2
;
Hui LIU
2
;
Jianjun MU
1
Author Information
- Publication Type:Journal Article
- Keywords: coronary stenosis; monocyte; high density lipoprotein; albumin; Gensini score
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(1):14-21
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the correlation of monocytes and high-density lipoprotein cholesterol ratio(MHR) and albumin with the severity of coronary artery lesions in patients with unstable angina pectoris. 【Methods】 We enrolled 342 patients with unstable angina pectoris. According to the Gensini score of their coronary angiography results, they were divided into Gensini≤ 20 group, 20
40 group. The differences in biochemical indicators between the groups were compared, and the correlation between the different indicators and the Gensini score was analyzed. According to the MHR quartile grouping, there were differences between the comparison groups. LDL-C was divided into subgroups and then subjected to multifactor Logistic regression analysis. 【Results】 MHR differed significantly among low, moderate and high grade lesions (P<0.05). Subgroup analysis showed that in low LDL-C group, Gensini score was positively correlated with MHR(P<0.05), while in high LDL-C group, Gensini score was negatively correlated with albumin(P<0.05). Multivariate Logistic regression analysis showed that the MHR level of patients with high Gensini score was 102.375 times higher than that of patients with low Gensini score(P<0.05). In the group with high LDL-C, the serum albumin level in the group with low Gensini score was 1.431 times that in the group with high Gensini score and 1.218 times that in the group with moderate Gensini score(all P<0.05). 【Conclusion】 In patients with unstable angina pectoris, especially when LDL-C levels are not high, both high MHR and low serum albumin are independent risk factors for the severity of coronary artery disease.
