Association between residual cholesterol and the risk of subclinical renal damage

Xi Zhang; Zejiaxin Niu; Guilin HU; Mingfei DU; Ting Zou; Xiaoyu Zhang; Lan Wang; Chao Chu; Yueyuan Liao; Qiong MA; Dan Wang; Keke Wang; Hao Jia; Chen Chen; Yu Yan; Yue Sun; Tongshuai Guo; Jie Zhang; Weihua Gao; Ziyue Man; Ke Gao; Wenjing Luo; Jianjun MU; Yang Wang

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Association between residual cholesterol and the risk of subclinical renal damage

VernacularTitle:残余胆固醇与亚临床肾损伤发生风险的相关性分析
Author: Xi ZHANG ¹ ; Zejiaxin NIU ¹ ; Guilin HU ¹ ; Mingfei DU ¹ ; Ting ZOU ¹ ; Xiaoyu ZHANG ¹ ; Lan WANG ² ; Chao CHU ¹ ; Yueyuan LIAO ¹ ; Qiong MA ¹ ; Dan WANG ¹ ; Keke WANG ¹ ; Hao JIA ¹ ; Chen CHEN ¹ ; Yu YAN ¹ ; Yue SUN ¹ ; Tongshuai GUO ¹ ; Jie ZHANG ³ ; Weihua GAO ⁴ ; Ziyue MAN ¹ ; Ke GAO ¹ ; Wenjing LUO ¹ ; Jianjun MU ¹ ; Yang WANG ^{1
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Author Information

1. Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061
2. Department of Cardiology, Xi’an International Medical Center Hospital, Xi’an 710100
3. Department of Cardiology, Xi’an People’s Hospital, Xi’an 710004
4. Department of Cardiology, Xi’an No.1 Hospital, Xi’an 710002
5. Global Health Institute, Xi’an Jiaotong University, Xi’an 710061, China
Publication Type:Journal Article
Keywords: residual cholesterol; subclinical renal damage; estimated glomerular filtration rate; albumin-to-creatinine ratio
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(1):6-13
CountryChina
Language:Chinese
Abstract: 【Objective】 Dyslipidemia has shown to be associated with cardiovascular, metabolic and renal diseases. This study aimed to investigate the association between residual cholesterol and the risk of subclinical renal damage (SRD). 【Methods】 A total of 2 342 participants were recruited from the previously established Hanzhong Adolescent Hypertension Study cohort. According to estimated glomerular filtration rate(eGFR) and urinary albumin-to-creatine ratio(uACR), the subjects were divided into SRD group and non-SRD group. The associations of residual cholesterol with eGFR, uACR, and the risk of SRD were analyzed by multiple linear and Logistic regression analyses. 【Results】 Residual cholesterol was positively correlated with uACR(r=0.081, P<0.001) but negatively correlated with eGFR (r=-0.091, P<0.001). Multiple linear regression analysis revealed that residual cholesterol was an influencing factor of uACR (β=0.075, P<0.001) and eGFR (β=-0.027, P<0.001) after adjustment for gender, age, smoke, alcohol, exercise, BMI, hypertension, diabetes and serum uric acid. In addition, Logistic regression analysis revealed that residual cholesterol was significantly associated with the risk of SRD independently of potential confounders [OR(95% CI)=1.387 (1.113-1.728), P<0.001]. Further subgroup analysis showed that residual cholesterol was significantly associated with the risk of SRD in women but not in men. 【Conclusion】 Residual cholesterol is a contributing factor in the risk of subclinical renal damage with gender-specific association.