Predictive value of preoperative albumin-to-alkaline phosphatase ratio for postoperative recurrence of limited penile cancer
10.3969/j.issn.1009-8291.2023.01.009
- VernacularTitle:术前白蛋白与碱性磷酸酶比值对局限性阴茎癌术后复发的影响
- Author:
Zhen SONG
1
;
Jun OUYANG
1
;
Qi ZHOU
2
;
Weijie ZHANG
1
;
Jianglei ZHANG
1
;
Zhiyu ZHANG
1
Author Information
1. Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou 215000, China
2. Center for Reproduction, The First Affiliated Hospital of Soochow University, Suzhou 215000, China
- Publication Type:Journal Article
- Keywords:
penile cancer;
squamous cell carcinoma;
albumin-to-alkaline phosphatase ratio;
recurrence;
prognosis
- From:
Journal of Modern Urology
2023;28(1):37-41
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the relationship between preoperative albumin-to-alkaline phosphatase ratio (AAPR) and postoperative recurrence of localized penile cancer (T1-3N0M0). 【Methods】 Clinical data of patients with limited penile cancer admitted to our hospital during Jan.2012 and Jan.2017 were collected to compare the differences in age, body mass index (BMI), AAPR, hypertension, diabetes mellitus, tumor diameter, postoperative pathological grading and staging between the postoperative recurrence group and the non-recurrence group. 【Results】 The differences in AAPR(P=0.001), WHO/ISUP pathological grading(P=0.018), and pathological stage(P=0.012)between the recurrence and non-recurrence groups were statistically significant. Cox regression results showed that AAPR was an independent risk factor for recurrence (P=0.041). Survival curve results showed that patients in the high and low AAPR groups had an inverse relationship with recurrence-free survival (P=0.028). 【Conclusion】 Preoperative AAPR is an independent risk factor for recurrence after surgery for limited penile cancer and is associated with recurrence-free survival. As AAPR increases, the incidence of recurrence decreases and progression-free survival increases.
