Recent advances in small-molecule inhibitors targeting influenza virus RNA-dependent RNA polymerase

VernacularTitle:靶向流感病毒RNA依赖的RNA聚合酶的小分子抑制剂研究进展
Author: Hui-nan JIA ; Rui-fang JIA ; Ji-wei ZHANG ; Yuan-min JIANG ; Chuan-feng LIU ; Ying ZHANG ; Xin-yong LIU ; Peng ZHAN
Publication Type:Research Article
Keywords: influenza virus; antiviral drug; RNA-dependent RNA polymerase; inhibitor; rug design
From: Acta Pharmaceutica Sinica 2024;58(1):43-60
CountryChina
Language:Chinese
Abstract: Influenza virus causes serious threat to human life and health. Due to the inherent high variability of influenza virus, clinically resistant mutant strains of currently approved anti-influenza virus drugs have emerged. Therefore, it is urgent to develop antiviral drugs with new targets or mechanisms of action. RNA-dependent RNA polymerase is directly responsible for viral RNA transcription and replication, and plays key roles in the viral life cycle, which is considered an important target of anti-influenza drug design. From the point of view of medicinal chemistry, this review summarizes current advances in diverse small-molecule inhibitors targeting influenza virus RNA-dependent RNA polymerase, hoping to provide valuable reference for development of novel antiviral drugs.