Research progress of nitrobenzoyl sesquiterpenoids as marine characteristic natural products
10.16438/j.0513-4870.2023-0419
- VernacularTitle:海洋特征天然产物——硝基苯酯倍半萜类的研究进展
- Author:
Yi CHEN
1
,
2
;
Jiang-lian SHE
1
,
2
;
Lan TANG
3
;
Yong-hong LIU
1
,
2
;
Xue-feng ZHOU
1
,
2
Author Information
1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
2. University of Chinese Academy of Sciences, Beijing 100049, China
3. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
- Publication Type:Research Article
- Keywords:
nitrobenzoyl sesquiterpenoid;
marine natural product;
italic>Aspergillus;
inhibition of osteoclast differentiation;
rug-likeness
- From:
Acta Pharmaceutica Sinica
2024;58(1):35-42
- CountryChina
- Language:Chinese
-
Abstract:
Sesquiterpenoids are widely found in nature, while nitrobenzoyl sesquiterpenoids are relatively rare. Twelve natural nitrobenzoyl sesquiterpenoids were all derived from marine Aspergillus fungi, which are typical natural products with marine characteristics. These natural products exhibit good antitumor, antiviral, and inhibition of osteoclast differentiation activity, especially in the treatment of osteoclast-related diseases, showing good medicinal development value. This article reviews the natural product sources, chemical structure, chemical synthesis, biosynthesis, bioactivity, and pharmacological mechanisms of nitrobenzoyl sesquiterpenoids and predicts and discusses their absorption, distribution, metabolism, excretion, toxicity (ADME/T), and drug-likeness, providing a comprehensive understanding of the natural products of nitrobenzoyl sesquiterpenoids from marine sources and their potential for pharmaceutical development.
