Progress on the relationship of aldehyde dehydrogenase 2 with human diseases and its small-molecule activators
10.12206/j.issn.2097-2024.202302038
- VernacularTitle:醛脱氢酶2与人类疾病的关系及其小分子激动剂研究
- Author:
Xiangpei SUN
1
,
2
;
Xing GAO
1
,
2
;
Fengping ZHAO
1
,
2
;
Wentao WANG
1
,
2
;
Tianyi ZHANG
1
,
2
;
Wei TIAN
3
,
4
;
Canhui ZHENG
2
;
Xin CHEN
5
Author Information
1. School of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China
2. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
3. School of Pharmacy, Naval Medical University, Shanghai 200433, China
4. General Hospital of Central Theater Command, Wuhan 430070, China.
5. School of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China.
- Keywords:
aldehyde dehydrogenase 2;
oxidative stress injury;
mutant;
ferroptosis;
small-molecule activators
- From:
Journal of Pharmaceutical Practice and Service
2024;42(1):6-11
- CountryChina
- Language:Chinese
-
Abstract:
Aldehyde dehydrogenase 2 (ALDH2) is one of important factors against from the damage under oxidative stress in human body. A high proportion of East Asians carry ALDH2 inactive mutation gene. There are many diseases closely related to ALDH2, such as cardiovascular diseases, neurodegenerative diseases and liver diseases. Recent studies also have found that ALDH2 is associated with ferroptosis. Therefore, ALDH2 has becoming a potential target for the treatment of the above related diseases. Several types of small molecule activators with potential value of clinical application have been reported. The research progress on the structure and function of ALDH2 , the relationship with human diseases and its activators were summarized in this paper.
