Association between 25-hydroxyvitamin D levels and incidence of allergy and infection in infants aged 0–6 months
https://doi.org/10.31246/mjn-2022-0059
- Author:
Maria Mexitalia
1
;
Yeni Kula Awang
1
;
Rina Pratiwi
1
;
Agustini Utari
1
Author Information
1. Department of Paediatrics, Faculty of Medicine, Universitas Diponegoro /Dr. Kariadi Hospital, Semarang, Indonesia
- Publication Type:Journal Article
- Keywords:
25(OH)D, allergy, infants, infection, umbilical cord blood
- From:
Malaysian Journal of Nutrition
2023;29(No.3):493-500
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Vitamin D levels are known to be related to prevalence of allergy and
infection in children. However, vitamin D levels in infants’ umbilical cord blood need
to be investigated. Therefore, this study aimed to determine association between
25-hydroxyvitamin D [25(OH)D] levels and incidence of allergy and infection
in children. Methods: A longitudinal study involving 38 full-term newborns
was conducted. Serum 25(OH)D levels in infants’ umbilical cord and venous
blood were measured at birth and six months, respectively. 25(OH)D levels were
classified as insufficient (<20 ng/mL) and sufficient (>20 ng/mL). Parents filled out
questionnaires about their children’s allergy and infection symptoms. Paired t-test
was performed to compare the 25(OH)D levels at birth and at six months. Chisquared test was conducted to determine relationship between 25(OH)D levels and
incidence of infection and allergy in children. Results: 25(OH)D levels in venous
blood of 6-month-old infants were significantly higher than in umbilical cord blood
(50.44±13.59 ng/mL vs. 20.70±6.60 ng/mL, p<0.001). In addition, 25(OH)D level
insufficiency in umbilical cord blood was associated with infection (p<0.05). However,
there was no incidence of allergy, and exclusive breastfeeding and sun exposure
were not associated with vitamin D levels in 6-month-old infants. Conclusion: We
conclude that 25(OH)D level insufficiency in umbilical cord blood was associated
with incidence of infection in the first six months of life.
- Full text:4.2023my0632.pdf
