Rice bran oil reduces organ-specific fat deposition, attenuates hyperlipidaemia and abnormal liver function in Long Evans rats with high fat intake
https://doi.org/10.31246/mjn-2022-0133
- Author:
Md. Jahangir Alam
1
;
Md. Kamrul Hasan
2
;
Md. Abdul Alim
1
;
Shamoli Akter
1
;
Khan Md. Murtaja Reza Linkon
1
;
Utpal Kumar Prodhan
1
Author Information
1. Department of Food Technology and Nutritional Science, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Tangail-1902, Bangladesh
2. Akij Food and Beverage Limited, Dhamrai, Dhaka, Bangladesh
- Publication Type:Journal Article
- Keywords:
fat depots, high fat diet, hyperlipidaemia, liver enzymes, rice bran oil
- From:
Malaysian Journal of Nutrition
2023;29(No.3):481-492
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: High-calorie diets, particularly the quality of dietary fats, are
regarded as an independent risk factor for developing obesity, hyperlipidaemia, and
liver diseases. The present study examined the impact of rice bran oil (RBO) on
organ-specific fat deposition, lipid profile, and liver function enzymes in Long Evans
rats. Methods: Long Evans rats (n=24) were fed for six weeks with a controlled
high-fat diet (HFD) to induce hyperlipidaemia and abnormal liver function. Rats
were then divided into two groups: one group continued feeding on HFD, and the
other group was fed with a RBO diet, replacing the fat source. After six weeks of
feeding, six rats from each group were sacrificed and required analytical tests were
performed. The remaining obese rats (n=12) were divided into continued HFD and
RBO diet, and after sacrificing, essential analytical tests were done. Results: RBO
feeding to hyperlipidaemic rats for six weeks significantly reduced brown adipose
tissue, abdominal adipose tissue, epididymal adipose tissue, and liver fat compared
to continuing HFD group (p<0.05). Similarly, serum levels of total cholesterol,
triacylglycerides, and low-density lipoprotein cholesterol were all decreased, whereas
high-density lipoprotein cholesterol increased in response to RBO compared to HFD
(p<0.05). Additionally, rats fed with RBO showed reduced alanine aminotransferase,
aspartate aminotransferase, and gamma-glutamyl transferase levels when compared
with continuing HFD-fed rats (p<0.05). Conclusion: These findings suggest that
RBO supports the reduction of fat storage from major fat depots, controls lipid
profile, and restores healthy liver functions in rats.
- Full text:4.2023my0631.pdf
