Research progress of mesenchymal stem cell-derived exosomes in the treatment of dry eye
10.3980/j.issn.1672-5123.2024.2.14
- VernacularTitle:间充质干细胞源性外泌体治疗干眼的研究进展
- Author:
Mingjie ZHANG
1
;
Congxin LI
1
;
Ying WEN
1
Author Information
1. Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
exosomes;
mesenchymal stem cells;
dry eye;
inflammation
- From:
International Eye Science
2024;24(2):251-254
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are extracellular vesicles that facilitate cellular communication by transmitting biomolecules and altering the biochemical characteristics of receptor cells. Mesenchymal stem cell-derived exosomes(MSC-Exos)are lipid bilayer vesicles secreted by mesenchymal stem cells(MSCs). These exosomes have similar functions to MSCs and contain bioactive substances such as proteins, lipids, and nucleic acids. MSC-Exos play a vital role in intercellular communication and are involved in essential physiological processes including immune regulation, tissue damage repair, and angiogenesis promotion. Consequently, they have gained significant attention in research, particularly in the treatment of immune inflammatory diseases, ischemic diseases, and other related fields. This article provides an in-depth analysis of the potential treatment mechanisms for dry eye, focusing on the pathogenesis of the condition, including inflammatory reactions, nerve regeneration, and tissue repair. The objective is to establish a foundation for the application of MSC-Exos in the treatment of dry eye, thereby offering a valuable reference for the future clinical applications.
