Research progress on the mechanisms of microglia in retinal angiogenesis
10.3980/j.issn.1672-5123.2024.2.12
- VernacularTitle:小胶质细胞在视网膜血管生成中的作用机制研究进展
- Author:
Chuanhan DAI
1
;
Longfei LIU
1
;
Chaopeng LI
1
Author Information
1. Department of Ophthalmology, the Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
microglia;
retinal angiogenesis;
neovascularization;
microenvironment;
signaling pathway
- From:
International Eye Science
2024;24(2):241-245
- CountryChina
- Language:Chinese
-
Abstract:
As resident immune cells of the retina, retinal microglia constantly monitor the changes of their surroundings and maintain homeostasis through signal transduction with other retinal cells. Retinal microglia play a crucial role not only in the development and physiological processes of the retinal vascular system, but also in pathological neovascularization. In certain retinopathies, activated microglia can stimulate abnormal angiogenesis through neurovascular coupling, leading to irreversible damage. However, the exact mechanisms underlying this process are still unclear. In this review, a brief overview of the relationship between microglia and retinal neovascularization was provided, and the involved cellular and molecular signaling mechanisms were reviewed, aiming to offer new and effective strategies for the prevention and treatment of retinal neovascularization diseases.
