Research progress of retinal neurovascular unit injury in glaucoma
10.3980/j.issn.1672-5123.2024.2.10
- VernacularTitle:青光眼中视网膜神经血管单元损伤的研究进展
- Author:
Lingyi OUYANG
1
;
Tao HE
1
;
Yiqiao XING
1
Author Information
1. Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
- Publication Type:Journal Article
- Keywords:
glaucoma;
retinal neurovascular unit;
retinal ganglion cell;
glial cell;
microvascular cell
- From:
International Eye Science
2024;24(2):230-235
- CountryChina
- Language:Chinese
-
Abstract:
Glaucoma is one of the leading causes of vision loss worldwide. More and more studies have suggested that glaucoma is a complicated retinal neurovascular disease. The homeostasis imbalance of retinal neurovascular unit(RNVU)composed of neurons, glial cells and microvascular cells not only induces changes in microvascular structure and glial cells, but also affects the nerve tissue of the retina, resulting in vision loss, which there is no effective treatment to reverse, currently. Exploring the cellular composition and molecular structure of RNVU and investigating the destruction mechanism of normal cellular environment and intercellular connections in glaucoma are of great significance in exploring the pathogenesis and the treatment of glaucoma. The research progress on structural changes and dysfunction of RNVU in glaucoma are reviewed, hoping to provide new ideas for the treatment of glaucoma.
