Protective effect of brain-derived neurotrophic factor on retinal neurovascular unit
10.3980/j.issn.1672-5123.2024.2.07
- VernacularTitle:脑源性神经营养因子对视网膜神经血管单元的保护作用
- Author:
Suyu WANG
1
;
Yujia YAO
1
;
Jiajun LI
1
;
Keran LI
1
Author Information
1. The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
neurovascular unit;
neurovascular coupling;
brain-derived neurotrophic factor;
retinal neurodegeneration
- From:
International Eye Science
2024;24(2):216-220
- CountryChina
- Language:Chinese
-
Abstract:
Based on the neurovascular unit(NVU), neurovascular coupling functions as a barrier to maintain the homeostasis of the microenvironment by regulating the signaling and metabolic activity of nerve cells and capillaries. Widely dispersed across the retina, the NVU is essential to preserving its normal physiological function. A disturbance in retinal neurovascular homeostasis produced by a range of factors can result in a variety of retinal disorders, such as diabetic retinopathy(DR), glaucoma, retinitis pigmentosa(RP)and age-related macular degeneration(ARMD). The retina also has a widespread distribution of brain-derived neurotrophic factor(BDNF), which functions to promote neuron growth and repair damage by binding to its receptor TrkB. In recent years, BDNF was found to play a protective role against damage in the early stage of retinal neurovascular homeostasis imbalance, often known as the neurodegenerative stage. It also helps to reduce the production of pro-angiogenic substances of neurological origin and offers a fresh approach for the early detection and treatment of associated eye disorders.
