Discussion on the Scientific Connotation of Fortifying Spleen， Resolving Phlegm and Dispelling Stasis in the Treatment of Coronary Heart Disease under the Guidance of Dysfunctional High-Density Lipoprotein
10.13288/j.11-2166/r.2024.02.002
- VernacularTitle:以失功能高密度脂蛋白为指导探讨健脾化痰祛瘀法治疗冠心病的科学内涵
- Author:
Lianqun JIA
1
;
Qige WANG
1
;
Guoyuan SUI
1
;
Nan SONG
1
;
Huimin CAO
1
;
Liang KONG
1
;
Meijun LV
1
;
Yuan CAO
1
;
Ning YU
1
;
Siyuan DING
1
;
Guanlin YANG
1
Author Information
1. Liaoning University of Traditional Chinese Medicine， Shenyang， 110847
- Publication Type:Journal Article
- Keywords:
coronary heart disease;
high density lipoprotein;
dysfunction;
binding of phlegm and stasis syndrome;
spleen deficiency
- From:
Journal of Traditional Chinese Medicine
2024;65(2):128-133
- CountryChina
- Language:Chinese
-
Abstract:
The key pathogenesis of coronary heart disease （CHD） is spleen deficiency and phlegm stasis， and dysfunctional high-density lipoprotein （dys-HDL） may be the biological basis for the occurrence of CHD due to spleen deficiency and phlegm stasis. Considering the biological properties and effects of high-density lipoprotein （HDL）， it is believed that the structure and components of HDL are abnormal in the state of spleen deficiency which led to dys-HDL； and dys-HDL contributes to the formation of atherosclerotic plaques through two major pathways， namely， mediating the dysfunction of endothelial cells and mediating the foaminess of macrophages and smooth muscle cells， thus triggering the development of CHD. It is also believed that dys-HDL is a microcosmic manifestation and a pathological product of spleen deficiency， and spleen deficiency makes foundation for the production of dys-HDL； dys-HDL is also an important biological basis for the phlegm-stasis interactions in CHD. The method of fortifying spleen， resolving phlegm， and dispelling stasis， is proposed as an important principle in the treatment of CHD by traditional Chinese medicine， which can achieve the therapeutic purpose by affecting the changes in the structure and components of dys-HDL， thus revealing the scientific connotation of this method， and providing ideas for the diagnosis and treatment of CHD by traditional Chinese medicine.
