Senescence Accelerated Mouse Prone 8 for Study of Alzheimer's Disease (review)
- VernacularTitle:快速老化小鼠SAMP8 在阿尔茨海默病研究中的应用
- Author:
Yan-zheng LI
;
Lin LI
;
Lan ZHANG
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease, senescence accelerated mouse prone 8, animal model, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2012;18(12):1119-1122
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive decline. The pathological eatures of Alzheimer's disease are abnormal deposition of amyloid beta-peptides (Aβ), neurofibrillary tangles, cholinergic deficits, and loss of synaptic processes and dendritic spines. Senescence accelerated mouse prone 8 exhibits age-related deficits of learning and memory from an early age, tau protein phosphorylation, neurotransmitter changes, synaptic structure and function disorders, circadian rhythm disorders,as well as gene expression and many other characteristic changes, which are consistent with Alzheimer's disease pathological changes，and can be used as an ideal animal model for Alzheimer's disease prevention drugs development.
