Effect and Mechanism of Chinese Medicine in Treatment of Osteoporosis
10.13422/j.cnki.syfjx.20231940
- VernacularTitle:中药抗骨质疏松作用及机制探讨
- Author:
Yulu YUAN
1
;
Zhen YANG
2
;
Wei DING
2
;
Ce CHU
1
;
Xuguang TAO
1
;
Xiangyun CHEN
2
;
Zhanzhan HE
1
;
Peizhang ZHAO
3
;
Yongqi XU
1
;
Yuxin ZHANG
1
;
Hongxia ZHAO
1
;
Wenlai WANG
1
Author Information
1. Institute of Basic Theory for Chinese Medicine， China Academy of Chinese Medical Sciences， Beijing 100700， China
2. Beijing University of Chinese Medicine， Beijing 100029， China
3. West China Clinical Medical College， Sichuan University， Chengdu 610041， China
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
effective part;
osteoporosis;
calcium metabolism;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(4):290-298
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis （OP） is a common bone disease affecting the quality of life and causing huge medical burden to the patients and society. The occurrence of OP is mainly caused by excessive bone resorption and insufficient bone formation， which are directly influenced by external calcium ion balance. Calcium imbalance can impair bone integrity， reduce the calcium supply to the bone， and lower the calcium content in the bone， thus triggering OP. Drugs are the main anti-OP therapy in modern medicine， which， however， may cause adverse reactions and drug dependence. Chinese medicines have good clinical effects and high safety in treating OP， being suitable for long-term use. Recent studies have shown that Chinese medicines can alleviate estrogen deficiency， regulate bone cell and calcium metabolism， which is crucial for the formation and development of OP. The transient receptor potential cation channel superfamily V members 5 and 6 （TRPV5 and TRPV6， respectively） affect bone homeostasis by mediating the transmembrane calcium ion transport in the intestine （TRPV6） and kidney （TRPV5）. Therefore， TRPV5/6 is one of the key targets to understand the anti-OP mechanisms of the effective parts of Chinese medicines， which is worthy of further study. This paper summarizes the research results about the anti-OP effects of Chinese medicines in the last two decades， especially the mechanism of regulating calcium metabolism， aiming to provide new ideas for the basic research， clinical application， and drug development of OP treatment.
