Mechanism of Ferroptosis in Myocardial Cells and Protective Effect of Traditional Chinese Medicine
10.13422/j.cnki.syfjx.20231202
- VernacularTitle:心肌细胞铁死亡的机制及中药的保护作用
- Author:
Haoran LI
1
;
Ce CAO
1
;
Lei LI
2
;
Jianxun LIU
2
Author Information
1. Research Institute of Traditional Chinese Medicine （TCM） of Guangdong Pharmaceutical University，Guangzhou 511436，China
2. Beijing Key Laboratory of TCM Pharmacology，Xiyuan Hospital，China Academy of Chinese Medical Sciences，National Research Center for Clinical Medicine of Cardiovascular Diseases of TCM，Beijing 100091，China
- Publication Type:Journal Article
- Keywords:
ferroptosis;
myocardial cells;
myocardial injury;
cardiovascular diseases （CVD）;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(4):260-270
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a new type of programmed cell death， characterized by iron overload and lipid peroxidation. Cardiovascular disease （CVD） is an ischemic or hemorrhagic disease of the heart caused by various factors， mainly including myocardial infarction， heart failure， etc. Ferroptosis is involved in the process of myocardial cell damage and plays a driving role in the progression of various CVDs. Its main mechanisms include the destruction of iron homeostasis， the production of reactive oxygen species， the disorder of the antioxidant system， mitochondrial membrane damage， endoplasmic reticulum stress， tumor suppressor gene p53， transcription factor Nrf2 pathway， etc. Myocardial injury is one of the causes of death in many patients with heart disease. Monomers or compounds of traditional Chinese medicine have shown good effects in the treatment of myocardial cell injury caused by ferroptosis， including baicalin protecting cardiac microvascular endothelial cells of myocardial ischemia-reperfusion （I/R） rats through intracellular phosphatidylinositol kinase/phosphokinase B/endothelial nitric oxide synthase （PI3K/Akt/eNOS） pathway， Aralia elata saponin inhibiting myocardial cell ferroptosis through glucocorticoid receptor/p53/solute carrier family 7 members 11 （NR3C1/p53/SLC7A11） pathway， Xinyang tablets improving oxidative stress by regulating phosphorylated serine/threonine protein kinase/stress-activated protein kinase/p53 （MLK3/JNK/p53） signaling pathway. It is of great significance to explore the mechanism of ferroptosis and the protective effect of related traditional Chinese medicine after myocardial cell injury. This article reviews the mechanism of ferroptosis and its relationship with myocardial cells， as well as traditional Chinese medicine monomers and formulas for treating CVDs through the ferroptosis pathway. The article focuses on the pathways and effects of traditional Chinese medicine treatment， so as to provide a reference for the treatment of CVDs with traditional Chinese medicine.
