Mechanism of Shengmaisan Regulating Cardiac Remodeling of Arrhythmias with Deficiency of Qi and Yin
10.13422/j.cnki.syfjx.20231101
- VernacularTitle:生脉散调控气阴两虚型心律失常的心脏重构机制探析
- Author:
Jingheng WEI
1
;
Xiaolu SHI
1
;
Wei YANG
2
;
Cong HUANG
1
;
Mengru SHI
2
;
Runhao MA
1
;
Mingjie SUN
1
Author Information
1. Key Laboratory of Traditional Chinese medicine Basic Research on Prevention and Treatment of Major Disease，Experimental Research Center，China Academy of Chinese Medical Sciences， Beijing 100700，China
2. Institute of Basic Theory for Chinese Medicine， China Academy of Chinese Medical Sciences，Beijing 100700，China
- Publication Type:Journal Article
- Keywords:
Shengmaisan;
arrhythmias;
cardiac remodeling;
deficiency of Qi and Yin;
nourishing Qi and Yin
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(4):248-259
- CountryChina
- Language:Chinese
-
Abstract:
Arrhythmia is an important disease among cardiovascular diseases. Malignant arrhythmias often occur clinically and are induced by abnormal ion channels， electrical activity disorders， myocardial fibrosis， inflammation， dysfunctional mitochondrial biogenesis， mitochondrial calcium overload， out-of-balance energy metabolism， oxidative stress， sympathetic hyperactivity， and other pathological cardiac remodeling， and they are the main causes of sudden cardiac death. In traditional Chinese medicine， arrhythmias are considered to be palpitations， which are commonly caused by deficiency of Qi and Yin. It is often manifested as a deficiency of the spleen and stomach， resulting in malfunction of the Qi mechanism， followed by a particularly severe decline in cardiac function. Shengmaisan is a representative formula for nourishing Qi and Yin， consisting of Ginseng Radix et Rhizoma， Ophiopogonis Radix， and Schisandrae Chinensis Fructus. In recent years， clinical studies have shown that Shengmaisan and its additions and subtractions are commonly used in the treatment of arrhythmias. In this article， the mechanisms of the active ingredients of Shengmaisan in the electrophysiology， biochemistry， structure， autonomic nervous system， and subcellular fraction of the heart are reviewed， and the multi-target， multi-system， and integrality of Shengmaisan in the treatment of arrhythmias of Qi and Yin deficiency are described. In addition， energy metabolism disorder is tightly juxtaposed with Qi and Yin deficiency syndrome. Mitochondria， as the center of myocardial energy metabolism， play a paramount role in cardiac remodeling， indicating that Shengmaisan will be a salient part of future research to ameliorate cardiac pathologic remodeling through energy metabolism of mitochondria， so as to provide a theoretical basis for the clinical treatment of these arrhythmias.
