Clinical Efficacy of Qingxin Zishen Decoction on Hot Flashes After Endocrine Therapy for Prostate Cancer and Its Preliminary Mechanism
10.13422/j.cnki.syfjx.20240993
- VernacularTitle:清心滋肾汤对前列腺癌内分泌治疗后潮热的疗效及初步机制研究
- Author:
Junjie GUO
1
;
Maosen ZHANG
2
;
Qingyi ZHU
3
Author Information
1. Wuxi Hospital of Traditional Chinese Medicine，Wuxi 214071，China
2. Jiangsu Province Hospital of Chinese Medicine，Nanjing 210029，China
3. The Second Affiliated Hospital of Nanjing Medical University，Nanjing 210011，China
- Publication Type:Journal Article
- Keywords:
Qingxin Zishen decoction;
hot flashes;
endocrine therapy;
prostate cancer;
vasomotor factor
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(4):152-158
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the clinical effect of Qingxin Zishen decoction on hot flashes after endocrine therapy for prostate cancer and explore its therapeutic mechanism. MethodA total of 60 patients who met the criteria and were admitted to Jiangsu Province Hospital of Chinese Medicine from December 2021 to December 2022 were collected and randomly divided into a treatment group and a control group， with 30 cases in each group. The treatment group was treated with Qingxin Zishen decoction， while the control group was only given routine nursing. The observation period of this study was eight weeks. The improvement of hot flash frequency， hot flash degree， hot flash score， ISS score， and TCM syndrome score were observed in the two groups before and after treatment. The changes of serum endothelin-1 （ET-1）， nitric oxide （NO）， calcitonin gene-related peptide （CGRP）， prostate specific antigen （PSA）， and testosterone were detected. ResultIn terms of efficacy， after treatment， the frequency， degree， and score of hot flashes， ISS score， and TCM syndrome score decreased in the treatment group （P<0.05）. Compared with the control group， all indicators were better in the treatment group （P<0.05）. In terms of laboratory indicators， after treatment， the serum NO level in the treatment group was increased. ET-1 level was decreased. The ratio of ET-1/NO was decreased， and the CGRP level was decreased （P<0.05）. However， testosterone and PSA levels were not significantly changed . Compared with the control group， after treatment， the serum NO level in the treatment group was higher， and the level of ET-1 was lower. The ratio of ET-1/NO and the CGRP level were lower （P<0.05）. There were no significant differences in testosterone and PSA levels between the two groups. ConclusionQingxin Zishen decoction can significantly improve hot flashes in patients with prostate cancer after endocrine therapy. The mechanism of Qingxin Zishen decoction may be to improve the vasomotor function by regulating the expression level of vasomotor factors， so as to treat hot flashes.
