Research progress in risk factors of post-transplantation diabetes mellitus
10.3969/j.issn.1674-7445.2023154
- VernacularTitle:移植后糖尿病危险因素研究进展
- Author:
Junfeng DONG
1
;
Qiang XUE
2
;
Fei TENG
1
;
Yuanyu ZHAO
1
;
Hao YIN
1
Author Information
1. Department of Organ Transplantation, the Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital), Shanghai 200003, China.
2. .
- Publication Type:ReviewArticle
- Keywords:
Organ transplantation;
Post-transplantation diabetes mellitus;
Calcineurin inhibitor;
Mammalian target of rapamycin inhibitor;
Glucocorticoid;
Cytomegalovirus;
Rejection;
Single nucleotide polymorphism
- From:
Organ Transplantation
2024;15(1):145-150
- CountryChina
- Language:Chinese
-
Abstract:
Solid organ transplantation has significantly prolonged the survival of patients with end-stage diseases. However, long-term use of immunosuppressants will increase the risk of post-transplantation diabetes mellitus (PTDM) in the recipients, thereby elevating the risk of infection, cardiovascular disease and death. In recent years, with persistent improvement of diagnostic criteria of PTDM, clinicians have deepened the understanding of this disease. Compared with type 2 diabetes mellitus, PTDM significantly differs in pathophysiological characteristics and clinical progression. Hence, different treatment strategies should be adopted. Early identification of risk factors of organ transplant recipients, early diagnosis and intervention are of significance for improving the quality of life of recipients, prolonging the survival of grafts and reducing the fatality of recipients. Therefore, the diagnosis, incidence and risk factors of PTDM were reviewed in this article, aiming to provide reference for clinicians to deliver prompt diagnosis and intervention for PTDM.
