Evolution and innovation of preservation fluid for donor liver
10.3969/j.issn.1674-7445.2023165
- VernacularTitle:供肝保存液的演变和革新
- Author:
Guotao YU
1
;
Yanfeng YIN
1
;
Chuntao YAN
1
;
Guangxu ZOU
1
;
Huangyan ZHANG
1
;
Li MA
1
;
Zongqiang HU
1
Author Information
1. Department of Hepatobiliary Pancreatic Surgery, the First People’s Hospital of Kunming, Kunming 650011, China.
- Publication Type:ReviewArticle
- Keywords:
Liver transplantation;
Donor liver;
Preservation fluid;
Cold ischemia injury;
Expanded criteria donor;
Marginal donor liver;
Oxidative stress;
Ischemia-reperfusion injury
- From:
Organ Transplantation
2024;15(1):131-137
- CountryChina
- Language:Chinese
-
Abstract:
Organ preservation fluid could mitigate cold ischemia injury and maintain normal function of the grafts. At present, how to reduce a series of injury caused by cold ischemia of donor liver and improve the preservation quality of grafts are the hot and challenging spots in this field. Currently, preservation fluid in clinical practice has not achieved ideal preservation effect, especially for the protection of marginal donor organs. In the context of severe donor shortage, the key solution is still to explore the optimal preservation protocol for donor liver to prevent grafts from cold ischemia injury. In this article, the mechanism of donor liver injury during cold ischemia, the classification and evolution of donor liver preservation fluid were summarized, the development direction and challenges of donor liver preservation fluid were discussed, aiming to provide novel ideas and references for the research and development of donor liver preservation fluid.
