Regulation mechanism of macrophage transition in renal fibrosis
10.3969/j.issn.1674-7445.2023190
- VernacularTitle:巨噬细胞转分化在肾纤维化中的调控机制
- Author:
Yanyan YANG
1
,
2
;
Tao TAO
1
,
2
;
Pengli LUO
2
Author Information
1. Research Center for High Altitude Medicine, Qinghai University, Key Laboratory of High Altitude Medicine of Ministry of Education, Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province (Qinghai-Utah Joint Research Key Lab for High Altitude Medicine), Xining 810001, China
2. .
- Publication Type:ReviewArticle
- Keywords:
Renal fibrosis;
Macrophage;
Myofibroblast;
Kidney transplantation;
Chronic kidney disease;
End-stage renal disease;
Transforming growth factor;
Smad3
- From:
Organ Transplantation
2024;15(1):125-130
- CountryChina
- Language:Chinese
-
Abstract:
Renal fibrosis is a common pathological change from development to end-stage renal diseases in all progressive chronic kidney diseases. Renal fibrosis after kidney transplantation will severely affect the renal graft function. Macrophages are characterized with high heterogeneity and plasticity. During the process of kidney injury, macrophages are recruited, activated and polarized by local microenvironment, and participate in the process of renal tissue injury, repair and fibrosis through multiple mechanisms. Recent studies have shown that macrophages may transit into myofibroblasts and directly participate in the formation of renal fibrosis. This process is known as macrophage-myofibroblast transition. Nevertheless, the regulatory mechanism remains elusive. In this article, the role of macrophages in renal fibrosis, the characteristics of macrophage-myofibroblast transition and the possible regulatory mechanism were reviewed, aiming to provide reference for relevant research of renal fibrosis.
