Research progress of traditional Chinese medicine in regulating Nrf2/HO-1 signaling pathway to interfere with myocardial ischemia-reperfusion injury
- VernacularTitle:中药调控Nrf2/HO-1信号通路干预心肌缺血再灌注损伤的研究进展
- Author:
Suxia JIA
1
;
Xiaomin XU
1
;
Huicong YANG
1
;
Shumin LIU
1
Author Information
1. Institute of Traditional Chinese Medicine，Heilongjiang University of Chinese Medicine，Harbin 150040，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
myocardial ischemia-reperfusion injury;
nuclear factor erythroid 2-related factor 2
- From:
China Pharmacy
2024;35(1):124-128
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial ischemia-reperfusion injury （MIRI） is a serious complication of revascularization in patients with myocardial infarction. The nuclear factor erythroid 2-related factor 2 （Nrf2）/heme oxygenase-1 （HO-1） signaling pathway plays an important role in the pathological process of MIRI. Currently，research has found that traditional Chinese medicine has a good effect on myocardial injury caused by ischemia-reperfusion. Based on the Nrf2/HO-1 signaling pathway，this article summarizes the action mechanism of traditional Chinese medicine formulas and monomers in intervening with MIRI. It is found that traditional Chinese medicine formulas （Yixin formula，Wenyang tongmai formula，Dingxin formula Ⅰ），monomers such as terpenoids （ginkgolides， astragaloside Ⅳ，ginsenosides），phenols （brazilin，hematoxylin A，resveratrol） and quinones （aloe，emodin） can alleviate MIRI by activating the Nrf2/HO-1 signaling pathway，inhibiting oxidative stress and inflammatory reactions，etc.
