Pharmacoeconomics of ivabradine in the treatment of CHF in the context of “Quadruple Therapy”
- VernacularTitle:“新四联”背景下伊伐布雷定治疗CHF的药物经济学评价
- Author:
Congling CHEN
1
,
2
;
Han WU
3
;
Jie ZHOU
1
,
2
;
Ruobin ZHANG
1
,
2
;
Jinping ZHANG
1
;
Xue BAO
3
;
Xian YANG
1
Author Information
1. Dept. of Pharmacy，Nanjing Drum Tower Hospital，Nanjing 210008，China
2. School of Basic Medicine and Clinical Pharmacy，China Pharmaceutical University，Nanjing 211198，China
3. Dept. of Cardiology，Nanjing Drum Tower Hospital，Nanjing 210008，China
- Publication Type:Journal Article
- Keywords:
chronic heart failure;
ivabradine;
Quadruple Therapy;
Markov model;
pharmacoeconomics
- From:
China Pharmacy
2024;35(1):63-68
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the cost-effectiveness of ivabradine in the treatment of chronic heart failure （CHF） in the context of “Quadruple Therapy” from the perspective of the health system. METHODS Based on real-world cohort data， the Markov model was constructed according to the natural progression of CHF， with a cycle time of 3 months， a study timeframe of 20 years， and a discount rate of 5%. Using quality-adjusted life year （QALY） and incremental cost-effectiveness ratios （ICER） as the output indexes， the cost-utility analysis was used to evaluate the cost-effectiveness of ivabradine in combination with the “Quadruple Therapy” regimen， compared with the “Quadruple Therapy” regimen for the treatment of CHF， and the robustness of the results of the base analysis was verified by univariate sensitivity analysis and probabilistic sensitivity analysis. RESULTS The results of the base analysis showed that the ICER of ivabradine combined with the “Quadruple Therapy” regimen was 165 065.54 yuan/QALY， compared with the “Quadruple Therapy” regimen， which was lower than the willingness-to-pay （WTP） threshold （257 094 yuan/QALY） based on 3 times of China’s gross domestic product （GDP） per capita in 2022. The results of the univariate sensitivity analysis showed that the discount rate had the greatest impact on the robustness of the model. The probabilistic sensitivity analysis showed that the probability that the ivabradine combined with the “Quadruple Therapy” regimen was cost-effective under the WTP threshold in this study was 59.50%. CONCLUSIONS When using 3 times China’s 2022 GDP per capita （257 094 yuan/ QALY） as the WTP threshold， the combination of ivabradine and the “Quadruple Therapy” regimen for treating CHF is cost- effective.
