Characteristics of tumor patients with anti-P1 antibody: a retrospective study
10.13303/j.cjbt.issn.1004-549x.2023.03.010
- VernacularTitle:肿瘤患者抗-P1特征回顾性研究
- Author:
Simeng CHEN
1
;
Jingjing YU
1
;
Juan CAI
1
;
Min LIU
1
;
Tao PENG
1
;
Weiwei FANG
1
;
Ruijuan ZHAO
1
;
Xiying LI
1
Author Information
1. Department of Blood Transfusion, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China
- Publication Type:Journal Article
- Keywords:
anti-P1;
tumor patients;
clinical characteristics;
alloantibody
- From:
Chinese Journal of Blood Transfusion
2023;36(3):235-237
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To evaluate the detection and distribution characteristics of anti-P1 in tumor patients, so as to aid in blood screening and transfusion safety. 【Methods】 The clinical data of 112 658 tumor patients who underwent blood preparation and transfusion in our hospital from January 2014 to December 2021 were retrospectively analyzed, and column agglutination technique was used to perform transfusion compatibility test. 【Results】 A total of 1 079 (0.96%, 1 079/112 658) cases were detected with unexpected antibodies, of which 71 (6.58%, 71/1 079) were identified as anti-P1. In anti-P1 cases, 59.15% (42/71) were males; 60.56% had no pregnancy history (P<0.01); 29.58% (21/71), 52.11%(37/71), 12.68%(9/71) and 5.63%(4/71) of anti-P1 patients were with type A, B, O and AB, respectively. 57 cases of anti-P1 patients (80.28%) had difficulty in ABO blood group identification. The incidence of interfering in patients with type B was higher than that of other blood types (P<0.05), as the frequency of w+ in reverse blood typing was higher than other reactive patterns (P<0.05). The incidence of gastric tumor and brain space-occupying lesion in patients with anti-P1 was higher than that in patients with other alloantibodies, while the incidence of gynecological tumors was lower (P<0.05). 【Conclusion】 Anti-P1 affects the ABO blood group identification of tumor patients, and most of them had difficulty in ABO blood group identification. Compared with patients with other alloantibodies, patients with anti-P1 are more likely to be male and suffer from gastric and brain tumors, but less likely from gynecological tumors.
