Preliminary Study on Quantitative Evaluation of Myocardial Fibrosis by CardiacMagnetic Resonance in Patients with Light Chain Cardiac Amyloidosis
10.12376/j.issn.2097-0501.2023.01.006
- VernacularTitle:心脏磁共振定量评价轻链型心脏淀粉样变患者心肌纤维化的初步研究
- Author:
Yubo GUO
1
,
2
;
Xuezhu WANG
2
,
3
;
Xiao LI
1
,
2
;
Yajuan GAO
2
,
4
;
Zhuang TIAN
2
,
5
,
6
;
Jian LI
2
,
4
;
Li HUO
2
,
3
;
Yining WANG
1
,
2
Author Information
1. Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
2. Peking Union Medical College, Beijing 100730, China.
3. Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
4. Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
5. Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
6. Peking Union Medical College, Beijing 100730, China.Department of International Medical Services, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
- Publication Type:Journal Article
- Keywords:
cardiac amyloidosis;
cardiac magnetic resonance;
myocardial fibrosis;
gallium-68-labeledfibroblast activation protein inhibitor
- From:
JOURNAL OF RARE DISEASES
2023;2(1):43-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective Myocardial fibrosis is a potential mechanism of light-chain myocardial amyloidosis(AL-CA). This research aimed at exploring the correlation between multiparameter cardiac magnetic resonance (CMR) and myocardial fibrosis by relating the CMR myocardial tissue characteristics, the morphological and the functional parameters with gallium-68-labeledfibroblast activation protein inhibitor 04 positron emission tomography (68Ga-FAPI PET). Methods We gave the patients diagnosed with AL-CA in Peking Union Medical College Hospital from August to December 2021 the examinations of CMR and 68Ga-FAPI PET/CT. We recorded and analyzed the information on clinical manifestations and examinations of the patients. Results A total of 23 patients with AL-CA were included, 15 (65.2%)of which were male and the mean age was 58.3±6.5 years. Patients with high 68Ga-FAPI-04 uptake had shown growth in myocardial extracellular volume (ECV), significantly higher than those in the negative group (P=0.047). In addition, patients' myocardial ECV was positively correlated with myocardial FAPI uptake (r=0.628, P=0.001;r=0.727, P < 0.001;r=0.661, P=0.001). Patients in the positive group showd reduced left ventricular (LV) ejection fraction (EF)(P < 0.001).LVEF (r=-0.798, P < 0.001;r=-0.794, P < 0.001; r=-0.795, P < 0.001) and right ventricular (RV)EF (r=-0.735, P < 0.001;r=-0.739, P < 0.001;r=- 0.684, P < 0.001) showd negatively correlated with myocardial FAPI uptake, LV circumferential strain (r=0.668, P < 0.001;r=0.708, P < 0.001;r=0.705, P < 0.001), LV longitudinal strain (r=0.629, P=0.001;r=0.635, P=0.001; r=0.597, P=0.003), and RV longitudinal strain (r=0.575, P=0.004; r=0.792, P < 0.001;r=0.673, P < 0.001) were negatively correlated with myocardial FAPI uptake. Conclusions FAPI-related fibroblast activation is concurrent with CMR-related abnormal myocardial interstitial characteristics that leads to the decreased function of the myocardial movement. Patients with increased FAPI uptake present with increased ECV, decreased EF, and decreased strain with morphological abnormalities.
