Four Cases of the Rare Skin Manifestation: Monoclonal-Proteinemia
10.12376/j.issn.2097-0501.2022.04.013
- VernacularTitle:M蛋白相关罕见皮肤病变四例
- Author:
Xianghong JIN
1
,
2
;
Junqing XU
1
,
3
;
Chen YANG
1
,
4
;
Tienan ZHU
1
,
4
;
Junling ZHUANG
1
,
4
Author Information
1. Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
2. Peking Union Medical College, Beijing 100730, China.Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
3. Peking Union Medical College, Beijing 100730, China.Department of Hematology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai 264000, China.
4. Peking Union Medical College, Beijing 100730, China.
- Publication Type:Journal Article
- Keywords:
M-proteinemia;
skin manifestations;
pyoderma gangrenosum;
erythema elevatum diutinum;
cutis laxa;
lichen myxedematosus
- From:
JOURNAL OF RARE DISEASES
2022;1(4):440-445
- CountryChina
- Language:Chinese
-
Abstract:
The skin manifestations of monoclonal(M)-proteinemia are rare and present in patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering plasma cell myeloma (SMM) and multiple myeloma (MM). In this study, we reported 4 cases with M-proteinemia-related rare skin lesions, including pyoderma gangrenosum (PG), erythema elevatum diutinum (EED), cutis laxa (CL) and lichen myxedematosus(LM). These skin lesions are specific, where the potential mechanism was immune-mediated paraneoplastic syndrome rather than direct plasma cell infiltration. Anti-plasma cell treatment was effective in treating skin lesions. The clinical outcome of MM-related skin changes was correlated to tumor control, whereas the prognosis of MGUS or SMM related skin lesions was favorable. Skin involvement in M-proteinemia is extremely rare and less well-known, which greatly impairs quality of life. The diagnosis and treatment of these 4 cases support the need for futher study.
