Skin Rash as the First Manifestation of Pediatric Chronic Neutrophilic Leukemia
10.12376/j.issn.2097-0501.2022.04.009
- VernacularTitle:以皮疹为首发表现的儿童期慢性中性粒细胞白血病
- Author:
Yabin ZHOU
1
;
Ruoyu DUAN
2
;
Jiafeng YAO
2
;
Maoquan QIN
3
;
Jianghong DENG
4
;
Zigang XU
1
;
Runhui WU
2
Author Information
1. Department of Dermatology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
2. Department 2 of Hemotology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
3. Department of Stem Cell Transplantation, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
4. Department of Rheumatology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
- Publication Type:Journal Article
- Keywords:
neutrophilia;
chronic neutrophilic leukemia;
leukemia cutis;
pediatric
- From:
JOURNAL OF RARE DISEASES
2022;1(4):413-419
- CountryChina
- Language:Chinese
-
Abstract:
A 6-year-old girl presented with recurrent skin rash at the initial stage, recent joint pain, and neutrophilia was found during a routine blood test. After a multidisciplinary case discussion, she was diagnosed with chronic neutrophil leukemia, and the symptoms were relieved after hydroxyurea and luxolitinib treatment. She received the allogeneic hematopoietic stem cell transplantation subsequently. At present, she is in stable condition and under follow-up. Chronic neutrophil leukemia is a rare disease, which rarely occurs in children. It is more difficult to diagnose in patients with skin rash as the first manifestation. The diagnosis and treatment of this case reflects the important role of multidisciplinary cooperation in the diagnosis and treatment of difficult and rare diseases.
