Consensus to 99mTechnetium-Pyrophosphate Scintigraphy in the Diagnosis of Transthyretin-related Cardiac Amyloidosis
10.12376/j.issn.2097-0501.2022.01.012
- VernacularTitle:锝[99Tcm]焦磷酸盐(99Tcm-PYP)单光子显像诊断转甲状腺素相关心脏淀粉样变操作指南
- Author:
Chao REN
1
,
2
,
3
;
Zhuang TIAN
2
,
3
,
4
;
Shan HE
2
,
3
,
4
;
Xuezhu WANG
1
,
2
,
3
;
Zhixin HAO
1
,
2
,
3
;
Jie DING
1
,
2
,
3
;
Shuyang ZHANG
2
,
3
,
4
;
Li HUO
1
,
2
,
3
Author Information
1. Department of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
2. Peking Union Medical College, Beijing 100730, China.State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
3. Peking Union Medical College, Beijing 100730, China.
4. Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
- Publication Type:Journal Article
- Keywords:
99mtechnetium-pyrophosphate;
transthyretin-related amyloidcardiomyopathy;
single-photon emission computed tomography
- From:
JOURNAL OF RARE DISEASES
2022;1(1):72-77
- CountryChina
- Language:Chinese
-
Abstract:
Transthyretin-related amyloid cardiomyopathy (ATTR-CM) is a disease caused by the depo-sition of insoluble amyloid fibers formed by the misfolding of transthyretin precursor protein in the intercellular space of cardiomyocytes. This lesion may lead to myocardial dysfunction, cogestive heart failure, and death.When diagnosed earlier, the patient can be treated with drugs as soon as possible to intervene in the progress of the disease, so as to effectively improve the patient's prognosis.99mtechnetium-pyrophosphate (99Tcm-PYP)single-photon emission computed tomography (SPECT) has been widely used in the imaging examination of cardiac amyloidosis (CA) in recent years. While achieving early non-invasive diagnosis, accurate pathological classification can be obtained through Perugini visual score analysis, semi-quantitative analysis of heart to contralateral lung (H/CL) ratio, and SPECT image analysis. This article presents the application, methods, and the precautions of 99Tcm-PYPSPECT in the diagnosis of ATTR-CM, aiming to provide clinical reference for the application of this technology.
