Necrolytic Migratory Erythema—A Case Report of Pancreatic Occupying Lesion
10.12376/j.issn.2097-0501.2023.03.014
- VernacularTitle:坏死松解性游走性红斑——胰腺占位一例
- Author:
Zhonghui HU
1
,
2
;
Lu YANG
1
,
2
;
Yuehua LIU
1
,
2
;
Hongzhong JIN
1
,
2
;
Qiang XU
2
,
3
;
Wenjing LIU
2
,
3
;
Yaping LUO
2
,
4
;
Hongbo YANG
2
,
5
;
Tao WANG
1
,
2
Author Information
1. Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
2. Peking Union Medical College, Beijing 100730, China.
3. Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
4. Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
5. Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
- Publication Type:Journal Article
- Keywords:
necrolytic migratory erythema;
glucagonoma;
glucagonoma syndrome;
pancreatic occupying lesion
- From:
JOURNAL OF RARE DISEASES
2023;2(3):427-431
- CountryChina
- Language:Chinese
-
Abstract:
Glucagonoma is a rare neuroendocrine tumor of α cells of the pancreas. The tumor excessively secretes glucagon and causes glucagonoma syndrome.70%-90% of patients with glucagonoma will develop necrolytic migratory erythema (NME). We reported a patient of glucagonoma syndrome who was presented to the dermatology outpatient clinic with a 2-year-history of recurrent erythema and scaling on the skin migrating throughout the body. A skin biopsy was performed and resulting features matched with NME, whilst imaging examinations suggested a soft tissue density tumor present in the tail of the pancreas with somatostatin receptor expression and laboratory tests found an elevated levels of serum glucagon. After the diagnosis was confirmed, the patient was treated with surgical resection of the glucagonoma and the skin eruptions resolved rapidly in 4 days. Meanwhile, we reviewed relevant literature published in recent years and summarized its clinical characteristics in order to improve its understanding by clinicians, including clinical manifestations, laboratory and imaging examinations, diagnosis and treatments.
