Irregular Menstruation-Hirsutism-Infertility: Clinical Management of Non-Classic Congenital Adrenal Hyperplasia
10.12376/j.issn.2097-0501.2023.03.013
- VernacularTitle:月经稀发-多毛-不孕：浅谈非经典型21-羟化酶缺乏症临诊应对
- Author:
Zhimei NIE
1
;
Jianxin DOU
2
;
Jin DU
1
;
Weijun GU
1
;
Zhaohui LYU
1
;
Jingtao DOU
1
;
Yiming MU
1
Author Information
1. Department of Endocrinology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
2. Department of Endocrinology, Weifang People′s Hospital in Shandong Province, Weifang 261041, China.
- Publication Type:Journal Article
- Keywords:
nonclassical 21-hydroxylase deficiency;
17-hydroxyprogesterone;
cosyntropin-stimulation test
- From:
JOURNAL OF RARE DISEASES
2023;2(3):420-426
- CountryChina
- Language:Chinese
-
Abstract:
A 38-year-old female presented with irregular menstruation and hirsutism that started at age of 16 and diagnosed with polycystic ovary syndrome at age of 29 with elevated testosterone. When treated with ethinestradiol cyproterone tablets, her menstruation returned to normal and androgen levels was not changed. At age of 38 she was referred to the hospital with infertility, a diagnosis of nonclassical 21-hydroxylase deficiency was confirmed using 17-hydroxyprogesterone, dehydroepiandrosterone-sulfate, a cosyntropin-stimulation test and genetic test. This case suggested that nonclassical congenital adrenal hyperplasia should be considered when a patient is presented with oligomenorrhea, hirsutism with hyperandrogenemia and infertility.
