5 Cases Analysis of Pachydermoperiostosis Complicated with Synovitis
10.12376/j.issn.2097-0501.2023.04.009
- VernacularTitle:5例厚皮骨膜增生症合并滑膜炎的临床特征分析
- Author:
Xin LU
1
,
2
;
Bo YANG
1
,
2
;
Jianguo ZHANG
1
,
2
,
3
Author Information
1. Department of Orthopaedic Surgery, Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Key Laboratory of Big Data for Spinal Deformities, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
2. Peking Union Medical College, Beijing 100730, China.
3. Peking Union Medical College, Beijing 100730, China.State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
- Publication Type:Journal Article
- Keywords:
pachydermoperiostosis;
clinical characteristics;
drug therapy;
surgery
- From:
JOURNAL OF RARE DISEASES
2023;2(4):523-528
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics, treatments and prognosis of pachydermoperiostosis (PDP) with synovitis, and to improve clinicians′ understanding of PDP. Methods The clinical data of 5 patients diagnosed with PDP in Peking Union Medical College Hospital from January 2010 to June 2015 were retrospectively analyzed. Results Among the 5 patients in this study, all were male, with an average age of (24.2±3.8)years old. The main manifestations of PDP were joint swelling and pain and skin thickening. In this study, all 5 patients were treated with medication, including non-steroidal anti-inflammatory drugs, glucocorticoids, and immunosuppressants, and 4 patients were treated with arthroscopic minimally invasive synovectomy. Their symptoms gradually improved and controlled. The last patient′s symptoms of synovitis were mild and significantly relieved after conservative treatment. Conclusions The diagnosis of PDP is still challenging. Symptoms can be alleviated, and the progression of the disease can be basically controlled after active drug therapy and surgical mitigation measures.
