Efficacy of apheresis platelet transfusion in 310 patients with haematological diseases
10.13303/j.cjbt.issn.1004-549x.2023.01.009
- VernacularTitle:310名血液病患者单采血小板输注效果分析
- Author:
Shisong YOU
1
;
Liqi LU
1
;
Qun CAI
1
;
Xiaomei LI
1
;
Xiulan HUANG
1
;
Jingwei ZHANG
1
Author Information
1. Chengdu Second People’s Hospital, Chengdu 610051, China
- Publication Type:Journal Article
- Keywords:
haematological disease;
platelet transfusion refractoriness;
apheresis platelet
- From:
Chinese Journal of Blood Transfusion
2023;36(1):36-41
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To observe the effect of platelet transfusion in inpatients with haematological diseases, analyze the possible causes of platelet transfusion refractoriness (PTR), in order to further improve the efficacy of platelet transfusion. 【Methods】 A total of 310 patients with blood disease in our hospital from August 2020 to November 2021 who received platelet transfusion were retrospectively analyzed. Possible influencing factors of platelet transfusion, including gender, age, platelet preservation time, number of platelet transfusions, complication and red blood cell product transfusion were analyzed. 【Results】 Patients were divided into effective group and refractory group according to percentage platelet recovery (PPR) and corrected count increment (CCI). PTR was defined as PPR <20% or CCI <5 000 after two consecutive transfusions in 24 h or clinical bleeding symptoms or tendency not significantly controlled. Statistical differences were noticed between the two groups in terms of gender, pretransfusion white blood cell count, anemia, and whether antibiotics were used (P<0.05). The type of disease, gender, anemia and number of comorbidities were associated with PTR. The incidence of PTR was the highest in patients with myelodysplastic syndrome, and the incidence of PTR was higher in men than in women. Transfusion units of suspended red blood cells and the number of comorbidities were negatively correlated with the transfusion efficacy (P<0.05). 【Conclusion】 Possible influencing factors of platelet transfusion included the level of white blood cells before transfusion, use of antibiotics, anemia and transfusion of red blood cells, number of comorbidities, and type of disease, while no significant differences were found in age, hemolysis, hypersplenism, platelet preservation time, and number of platelet transfusions on transfusion efficacy.
